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Assessment of whether and how phenylephrine infusion reduces postoperative shivering in spinal anaesthesia.
This study aims to evaluate whether phenylephrine infusion can reduce postoperative shivering among patients scheduled for elective lower segment caesarean section under spinal anaesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A (Phenylephrine) | Experimental | Phenylephrine infusion started immediately after administration of spinal block |
|
| Group B (Saline) | Placebo Comparator | Normal saline infusion started immediately after administration of spinal block |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phenylephrine | Drug | Phenylephrine infusion 0.3ml/kg/hour (equivalent to 0.5mcg/kg/min, phenylephrine dilution is 100mcg/ml in 20ml syringe) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Presence and intensity of shivering | Any presence of shivering intraoperatively is recorded. The intensity of shivering is recorded based on the Bedside Shivering Assessment Scale (BSAS) with a scoring of 0-3 (0 = no shivering, 1 = shivering localised to neck and/or thorax, 2 = shivering involves gross movement of upper extremities, 3 = shivering involves gross movements of the trunk, upper and lower extremities). | 2 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Change in patient's core and skin temperature | Patient's core (tympanic membrane) and skin (forehead) temperature is measured using an infrared thermometer. | 2 hours |
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Inclusion Criteria:
Exclusion Criteria:
Patients who are planned for elective lower segment caesarean section
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| Name | Affiliation | Role |
|---|---|---|
| Syarifah Noor Nazihah Sayed Masri, MD | Anaesthesiologist | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pusat Perubatan Universiti Kebangsaan Malaysia | Kuala Lumpur | 56000 | Malaysia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 10439767 | Background | Ikeda T, Ozaki M, Sessler DI, Kazama T, Ikeda K, Sato S. Intraoperative phenylephrine infusion decreases the magnitude of redistribution hypothermia. Anesth Analg. 1999 Aug;89(2):462-5. doi: 10.1097/00000539-199908000-00040. | |
| 20146867 | Background | Ro Y, Huh J, Min S, Han S, Hwang J, Yang S, Kim DK, Kim C. Phenylephrine attenuates intra-operative hypothermia during spinal anaesthesia. J Int Med Res. 2009 Nov-Dec;37(6):1701-8. doi: 10.1177/147323000903700605. |
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| ID | Term |
|---|---|
| D010656 | Phenylephrine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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| Normal saline | Drug | Normal saline infusion 0.3ml/kg/hour (normal saline in 20ml syringe) |
|
| 32500108 | Background | Hilton EJ, Wilson SH, Wolf BJ, Hand W, Roberts L, Hebbar L. Effect of Intraoperative Phenylephrine Infusion on Redistribution Hypothermia During Cesarean Delivery Under Spinal Anesthesia. J Clin Anesth Manag. 2016 Jan;1(1):10.16966/2470-9956.103. doi: 10.16966/2470-9956.103. Epub 2015 Dec 19. |
| 18927450 | Background | Badjatia N, Strongilis E, Gordon E, Prescutti M, Fernandez L, Fernandez A, Buitrago M, Schmidt JM, Ostapkovich ND, Mayer SA. Metabolic impact of shivering during therapeutic temperature modulation: the Bedside Shivering Assessment Scale. Stroke. 2008 Dec;39(12):3242-7. doi: 10.1161/STROKEAHA.108.523654. Epub 2008 Oct 16. |
| D000588 |
| Amines |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |