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The researchers are trying to evaluate how much medication is required for allergy skin testing and to determine the likelihood that patients with a negative test truly don't have an allergy to the tested drug of skin testing to commonly used antibiotics.
This study will be a prospective study to accurately determine the negative predictive value of skin testing with beta lactam containing antibiotics other than penicillin .
It is hypothesized that the concentrations that should be used for beta lactams are actually much lower than previously recommended and that the higher incidence of identifiable beta lactam induced allergic reactions during anesthesia in the past may be due to irritation of the skin rather than a true allergic reaction (false positives).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study Group | Experimental | Study team is developing a new diagnostic skin testing procedure for patients who receive beta lactam containing antibiotics during surgery (other than penicillin) in order to determine Negative Predictive Values and Non-Irritant Concentrations. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Skin Testing beta-lactams | Diagnostic Test | Percutaneous skin prick followed by Intradermal Injections of NMBAs at increasing concentrations compared with an established positive and negative control. |
| Measure | Description | Time Frame |
|---|---|---|
| Non-Irritant Concentrations to common beta lactam containing antibiotics other than penicillin | Determine the NIC to common beta lactam containing antibiotics | 1 Year |
| Measure | Description | Time Frame |
|---|---|---|
| Negative Predictive Value of Intradermal Skin Testing to commonly used beta lactam containing antibiotics other than penicillin | Determine Negative Predictive Value of Intradermal Skin Testing to commonly used beta lactam containing antibiotics | 1 Year |
| Measure | Description | Time Frame |
|---|---|---|
| Max Concentration used when skin testing to beta lactam containing antibiotics other than penicillin | Close gap on the variability of the maximal concentration used when skin testing beta lactam containing antibiotics. | 1 Year |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alexei Gonzalez Estrada, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic in Florida | Jacksonville | Florida | 32224 | United States | ||
| Mayo Clinic |
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| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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| ID | Term |
|---|---|
| D006967 | Hypersensitivity |
| ID | Term |
|---|---|
| D007154 | Immune System Diseases |
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Skin testing
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| Jacksonville |
| Florida |
| 32224 |
| United States |