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The researchers are trying to develop an allergy skin test to help predict allergic responses to medications commonly given to patients during surgery.
This study will be a prospective study to accurately determine the negative predictive value of skin testing with NMBAs.
It is hypothesized that the concentrations that should be used for NMBAs are actually much lower than previously recommended and that the higher incidence of identifiable NMBA induced allergic reactions during anesthesia in the past may be due to irritation of the skin rather than a true allergic reaction (false positives).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study Group | Experimental | Study team is developing a new diagnostic skin testing procedure for patients who receive NMBAs during surgery in order to determine Negative Predictive Values and Non-Irritant Concentrations. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Skin Testing | Diagnostic Test | Percutaneous skin prick followed by Intradermal Injections of NMBAs at increasing concentrations compared with an established positive and negative control. |
| Measure | Description | Time Frame |
|---|---|---|
| Non-Irritant Concentrations to common NMBAs | Determine the NIC to common NMBAs | 1 Year |
| Measure | Description | Time Frame |
|---|---|---|
| Negative Predictive Value of Intradermal Skin Testing to commonly used NMBAs | Determine Negative Predictive Value of Intradermal Skin Testing to commonly used NMBAs | 1 Year |
| Max Concentration used when skin testing to NMBAs |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alexei Gonzalez Estrada, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic | Jacksonville | Florida | 32224 | United States |
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| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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| ID | Term |
|---|---|
| D006967 | Hypersensitivity |
| ID | Term |
|---|---|
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D012882 | Skin Tests |
| ID | Term |
|---|---|
| D007159 | Immunologic Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Close gap on the variability of the maximal concentration used when skin testing NMBAs.
| 1 Year |
| D008919 | Investigative Techniques |
| D007158 | Immunologic Techniques |