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Two drugs (Piroxicam and Prednisolone)are being compared for post operative endodontic pain after a single visit root canal treatment for 74 hours.
To evaluate effectiveness of single dose premedication with piroxicam(20mg) and prednisolone(20mg) on post endodontic pain after a single visit root canal treatment .
patient will be recalled every day for 4 days to know the pain scale using visual analogue scale .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | No Intervention | group 1 , is no intervention group in which root canal procedure will be done without drug as ideal protocol . | |
| Piroxicam | Experimental | group 2 is given Piroxicam 20 mg half an hour before root canal treatment to manage post operative pain. |
|
| Prednisolone | Experimental | group 3 is given Prednisolone 20mg half an hour before root canal treatment to manage post operative pain. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Piroxicam 20 mg | Drug | Piroxicm is from oxicam family of anti inflammatory drug that inhibits prostaglandin synthesis and effectively lower pain threshold levels |
|
| Measure | Description | Time Frame |
|---|---|---|
| post operative pain | post operative pain will be measured after single visit endodontic treatment using visual analog scale with readings 1 to 10 from 24 hours till 76 hours | 76 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anum Tanwir, BDS | Dow University of Health Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| DUHS | Karachi | Sindh | 75500 | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36217645 | Derived | Tanwir A, Ahmed S, Akhtar H, Wahid U, Shakoor Abbasi M, Ahmed N. Effectiveness of Single Dose Premedication of Piroxicam and Prednisolone on Post Endodontic Pain in One Visit Root Canal Treatment: A Randomized Clinical Trial. Eur Endod J. 2022 Oct;7(3):187-192. doi: 10.14744/eej.2022.24119. |
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| ID | Term |
|---|---|
| D010894 | Piroxicam |
| D011239 | Prednisolone |
| ID | Term |
|---|---|
| D013843 | Thiazines |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D006573 | Heterocyclic Compounds, 1-Ring |
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subjects are randomly placed into one of the three groups: Placebo, Piroxicam (20 mg), Prednisolone (20 mg). The drugs will be given thirty minutes before procedure starts,followed by one visit root canal procedure. Postoperative pain will be evaluated up to 96 hours interval using a visual analog scale.
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It is a double blinded study in which investigator /caregiver and participant will be blinded and 3rd person not in the study will be dispatching drugs from the coded bottles .
| prednisolone 20 mg | Drug | prednisolone is from steroid family of anti inflammatory drug that inhibit arachidonic acid and effectively lowers the pain |
|
| D006571 |
| Heterocyclic Compounds |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |