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the study is conducted to assess and compare the efficacy of local intraligamentary injection of glucocorticoids(dexamethasone) and NSAID(piroxicam) on reduction of postoperative pain in patients with symptomatic irreversible pulpitis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dexamethasone | Experimental | Pretreatment intraligamentary injection of 0.4 mL of 8 mg/2 mL dexamethasone (Dexamethasone, AMRIYA pharmaceutical, Egypt) |
|
| piroxicam | Experimental | Pretreatment intraligamentary injection of 0.4 mL of 20 mg mL-1 piroxicam (Feldene, Pfizer, Egypt) |
|
| Mepivacaine HCL | Active Comparator | Pretreatment Intraligamentary injection of 0.4 mL of Mepivacaine HCl 36 mg /1.8 ml + Levonordefrin HCl 0.108 mg/ 1.8 ml (Mepecaine - L, Alexandria Co.-Egypt) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexamethasone sodium phosphate | Drug | prophylactic intraligamentary supplemental injection of 0.4 ml of 8 mg/2 mL dexamethasone. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Post operative pain assessed with the Numerical Rating Pain Scale | Intensity of pain after endodontic treatment is recorded by the patient using a numerical rating scale(where 0= no pain ,1-3 =mild pain ,4-6= moderate pain and 7-9= severe pain ) | up to 48 hours after root canal treatment (At 4,6,12,24 and 48 hours after root canal treatment ). |
| Measure | Description | Time Frame |
|---|---|---|
| number of analgesics taken by the patient | Number of analgesic tablets taken by the patient after endodontic treatment. | Until 48 hours after endodontic treatment. |
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Inclusion Criteria:
Systemically healthy patient (ASA I or II).
Mandibular Posterior teeth with:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Safwa Es. Abd Elglil, B.D.S. (Cairo University) | Contact | 01001259618 | 002 | safwaessam91@gmail.com |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27790253 | Background | Mehrvarzfar P, Esnashari E, Salmanzadeh R, Fazlyab M, Fazlyab M. Effect of Dexamethasone Intraligamentary Injection on Post-Endodontic Pain in Patients with Symptomatic Irreversible Pulpitis: A Randomized Controlled Clinical Trial. Iran Endod J. 2016 Fall;11(4):261-266. doi: 10.22037/iej.2016.2. | |
| 22432824 | Background |
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| Piroxicam Injectable Solution | Drug | prophylactic intraligamentary supplemental injection of 0.4 mL of 20 mg mL-1 piroxicam |
|
| Mepivacaine HCL | Drug | prophylactic intraligamentary supplemental injection 0.4 mL of Mepivacaine HCl 36 mg /1.8 ml + Levonordefrin HCl 0.108 mg/ 1.8 ml |
|
| Atbaei A, Mortazavi N. Prophylactic intraligamentary injection of piroxicam (feldene) for the management of post-endodontic pain in molar teeth with irreversible pulpitis. Aust Endod J. 2012 Apr;38(1):31-5. doi: 10.1111/j.1747-4477.2010.00274.x. Epub 2010 Oct 24. |
| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| C004180 | dexamethasone 21-phosphate |
| D008619 | Mepivacaine |
| ID | Term |
|---|---|
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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