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VDR and TFIP11 Gene polymorphism and gene-environment interactions on caries etiology and susceptibility in adults.
To date, genes can be grouped into categories based on the factor influencing dental caries. The major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits.
TFIP11 and VDR genes are related to enamel formation genes
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high caries experience | 80 adults will be allowed in the high caries experience group according to DMFT index DMFT>13.9 |
| |
| low caries experience | 80 adults will be allowed in the high caries experience group according toDMFT index DMFT≤4 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| high caries experience | Genetic | DNAs were obtained from epithelial cells in buccal mucosa and were extracted with Genomic DNA Isolation Kit |
|
| Measure | Description | Time Frame |
|---|---|---|
| past caries experience | Each tooth will be examined and recorded as decayed, missing, or filled | 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Plaque index | The plaque amount is scored by using Silness&Löe Plaque Index plaque index PI<1.0 healthy PI 1.1-2.0 mild PI>2 high plaque | 3 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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160 adult in the 24-40 age range living in Northeast Turkey will allowed in the study
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| Name | Affiliation | Role |
|---|---|---|
| Gül Yıldız Telatar, dr | Recep Tayyip Erdogan University Dentistry Faculty | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Recep Tayyip Erdogan University Dentistry Faculty | Rize | 53000 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27472568 | Background | Cogulu D, Onay H, Ozdemir Y, Aslan GI, Ozkinay F, Eronat C. The Role of Vitamin D Receptor Polymorphisms on Dental Caries. J Clin Pediatr Dent. 2016;40(3):211-4. doi: 10.17796/1053-4628-40.3.211. |
| Label | URL |
|---|---|
| The Role of Vitamin D Receptor Polymorphisms on Dental Caries. | View source |
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Data will be available within 6 months of study completion
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| ID | Term |
|---|---|
| D005838 | Genotype |
| ID | Term |
|---|---|
| D055614 | Genetic Phenomena |
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DNA for genetic analysis was isolated from buccal epithelial cells
|