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| ID | Type | Description | Link |
|---|---|---|---|
| A074600 | Other Identifier | UW, Madison | |
| AG&LSC/NUTRITIONAL SCI/NUTRITI | Other Identifier | UW, Madison |
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| Name | Class |
|---|---|
| National Institute of Health Research and Development, Ministry of Health Republic of Indonesia | OTHER |
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Women of reproductive age had their vitamin A stores estimated by retinol isotope dilution and then were given vitamin A supplements near the US vitamin A RDA or placebo for 42(USA) or 60 (Indonesia) days, after which retinol isotope dilution was repeated and the change in vitamin A stores was determined in each group to estimate how much vitamin A is needed to maintain nutrient balance in these women.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vitamin A supplement | Experimental | Subjects receive a vitamin A supplement containing 175 or 525 micrograms of vitamin A as retinyl palmitate daily |
|
| Placebo | Placebo Comparator | Subjects receive an oil placebo containing no vitamin A |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin A supplement | Dietary Supplement |
| ||
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Total body vitamin A stores (micromoles of vitamin A) | Change in total body stores of vitamin A before and after intervention, measured by retinol isotope dilution | Baseline and after 42 to 60 days |
| Total vitamin A liver reserves (micromoles vitamin A per gram liver) | Change in total liver reserves of vitamin A before and after intervention, measured by retinol isotope dilution | Baseline and after 42 to 60 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sherry A Tanumihardjo, PhD | University of Wisconsin, Madison | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Wisconsin - Madison | Madison | Wisconsin | 53706 | United States | ||
| Pusat Teknologi Terapan Kesehatan dan Epidemiologi Klinik |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32492125 | Derived | Sheftel J, Valentine AR, Hull AK, Fadjarwati T, Gannon BM, Davis CR, Tanumihardjo SA. Findings in 3 clinical trials challenge the accuracy of the Institute of Medicine's estimated average requirements for vitamin A in children and women. Am J Clin Nutr. 2021 May 8;113(5):1322-1331. doi: 10.1093/ajcn/nqaa132. |
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| ID | Term |
|---|---|
| D014802 | Vitamin A Deficiency |
| ID | Term |
|---|---|
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
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Parallel assignment to 0 or 525 micrograms supplemental vitamin A/day (Indonesia) or 0, 175 or 525 micrograms supplemental vitamin A/day (USA).
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Participants blinded (Indonesian), double blinded (USA)
|
| Bogor |
| Indonesia |
| D009750 |
| Nutritional and Metabolic Diseases |