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| ID | Type | Description | Link |
|---|---|---|---|
| A074600 | Other Identifier | UW, Madison | |
| AG&LSC/NUTRITIONAL SCI/NUTRITI | Other Identifier | UW, Madison |
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Women were given a vitamin A tracer, and blood was sampled to determine individual and group vitamin A kinetics. Data were subsequently modeled using compartmental analysis to determine effects of study length on model outcomes.
This is a longitudinal study in which American women were given an oral, stable isotope tracer of vitamin A, and blood was sampled in a staggered, serial design to determine individual and group vitamin A kinetics. Data were subsequently modeled using compartmental analysis, and study truncation analysis was performed on data to investigate the factor of study duration on resulting vitamin A kinetic models and outputs related to vitamin A metabolism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vitamin A tracer | Experimental | A stable isotope tracer of vitamin A was given orally. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin A tracer | Other | A stable isotope tracer of vitamin A was given orally. |
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| Measure | Description | Time Frame |
|---|---|---|
| Total traced vitamin A mass | Total amount of endogenous vitamin A determined by mathematical model, (µmol). | Baseline through 152 days |
| Measure | Description | Time Frame |
|---|---|---|
| Compartmental model complexity | Required number of compartments in mathematical model needed to adequately fit data. | Baseline through 152 days |
| Compartmental model fractional transfer coefficients |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sherry A Tanumihardjo, PhD | University of Wisconsin, Madison | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Nutritional Sciences, University of Wisconsin-Madison | Madison | Wisconsin | 53706 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30137477 | Derived | Gannon BM, Valentine AR, Davis CR, Howe JA, Tanumihardjo SA. Duration of Retinol Isotope Dilution Studies with Compartmental Modeling Affects Model Complexity, Kinetic Parameters, and Calculated Vitamin A Stores in US Women. J Nutr. 2018 Aug 1;148(8):1387-1396. doi: 10.1093/jn/nxy095. |
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Model parameters adjusted to fit analytical data. Represents the fractional transfer from one compartment to another in the model, (pools/d, represented as L(i,j), the fraction of compartment J transferred to compartment I per day).
| Baseline through 152 days |
| Serum vitamin A half-life | Half-life of vitamin A in serum, (d). | Baseline through 152 days |
| Vitamin A disposal rate | Daily loss or utilization of vitamin A, (µmol/d). | Baseline through 152 days |
| Vitamin A equilibration time and partitioning | Time taken for vitamin A to equilibrate with body stores, (d). | Baseline through 152 days |
| Vitamin A tracer partitioning | Body partitioning of tracer between serum and extravascular compartment(s), relative to total tracee mass. Calculated as a ratio of tracer-to-tracee ratio (TTR) in serum and extravascular stores, (TTR serum / TTR stores). | Baseline through 152 days |
| Vitamin A dietary intake | Vitamin A dietary intake by food frequency questionnaire, (µg retinol activity equivalents/d). | Baseline |