Vitamin A Kinetics and Mathematical Modeling in American Women

Vitamin A Kinetics and Mathematical Modeling in American Women

Women were given a vitamin A tracer, and blood was sampled to determine individual and group vitamin A kinetics. Data were subsequently modeled using compartmental analysis to determine effects of study length on model outcomes.

This is a longitudinal study in which American women were given an oral, stable isotope tracer of vitamin A, and blood was sampled in a staggered, serial design to determine individual and group vitamin A kinetics. Data were subsequently modeled using compartmental analysis, and study truncation analysis was performed on data to investigate the factor of study duration on resulting vitamin A kinetic models and outputs related to vitamin A metabolism.

Inclusion Criteria:

• BMI (18.5 - 24.9 kg/m2)

Exclusion Criteria:

• Smoker
• Pregnant
• Trying to become pregnant
• Lactating
• Weight loss > 4.5 kg during the past 3 months.
• Actively trying to lose weight
• Inability to refrain from drinking alcohol when requested
• Amenorrhea
• Acute or chronic illness including hepatitis
• Current or previous history of anorexia or bulimia
• Concurrent participation in other studies
• Family member already enrolled in the study