Time Course of Postprandial Protein Metabolism

Time-dependent Regulation of Postprandial Muscle Protein Synthesis After Milk Protein Ingestion in Young Men

The anabolic action of 'fast' whey protein on the regulation of postprandial muscle protein synthesis has been established to be short-lived in healthy young adults. Our aim was assess the time course of anabolic signaling events and stimulation of muscle protein synthesis rates (MPS) after ingestion of a food source that represents a more typical meal-induced pattern of aminoacidemia, namely milk protein concentrate, in healthy young males.

Inclusion criteria

• Males
• Aged between 18-35 years
• Healthy, recreationally active
• BMI < 30 kg/m2

Exclusion criteria

• Smoking
• Allergies to milk proteins
• Vegetarians
• Diagnosed GI tract diseases
• Female
• Arthritic conditions
• A history of neuromuscular problems
• Previous participation in amino acid tracer studies
• Predisposition to hypertrophic scarring or keloid formation
• Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).