Autonomic Regulation in Prader-Willi Syndrome

Impact of Sleep-disordered Breathing on Autonomic Regulation in Patients With Prader-Willi Syndrome

To evaluate autonomic regulation in patients with Prader-Willi syndrome with sleep-disordered breathing.

To evaluate the relationship between narcolepsy and sleep-disordered breathing, the natural course of untreated or treated sleep-disordered breathing and its impacts on autonomic regulation in patients with Prader-Willi syndrome with sleep-disordered breathing.

Inclusion Criteria:

• 7-75 y/o Prader-Willi syndrome patients or healthy subjects
• can perform polysomnography, multiple sleep latency test
• orthostatic methods for autonomic function test
• can perform pulmonary function test.

Exclusion Criteria:

• less than y/o, or larger then 75 y/o
• cannot perform polysomnography, multiple sleep latency test
• cannot orthostatic methods for autonomic function test
• cannot perform pulmonary function test
• use of sedatives or drugs affecting autonomic function