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The purpose of this study is to examine the effect of acute ingestion of a concentrated beetroot juice supplement on vascular function and exercise capacity in patients with moderate to severe chronic kidney disease
People with Chronic Kidney Disease (CKD) are at an increased risk of cardiovascular disease. Blood vessel dysfunction and exercise intolerance are common in CKD. Blood vessel dysfunction has been shown to predict future cardiovascular events and decreased physical activity can contribute to an increased risk of cardiovascular disease. Therefore, this study investigates if dietary nitrate from beetroot juice, which has been shown to improve blood vessel function and exercise capacity in other cardiovascular disease pathologies, could be effective at improving these measures in patients with CKD. In a controlled, double blinded trial, stage 3-5 CKD patients will be randomly assigned to receive either beetroot beverage or a placebo and then complete measures of blood vessel function and an exercise test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Beet Juice Supplement | Experimental | A single, acute dose of Beet It Sport Shot containing ~12.6mmol naturally occurring dietary nitrates. |
|
| Placebo juice | Placebo Comparator | A single, acute dose of nitrate-depleted Beet It Sport Shot |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beet It Sport Shot | Dietary Supplement | Source of naturally occurring dietary nitrates |
|
| Measure | Description | Time Frame |
|---|---|---|
| Microvascular Function, assessed by laser Doppler flowmetry coupled with intradermal microdialysis | Nitric oxide mediated cutaneous microvascular dilatory response to local heating assessed by laser Doppler flowmetry coupled with microdialysis | 2.5 hours post ingestion of juice |
| Measure | Description | Time Frame |
|---|---|---|
| Endothelial function | Conduit artery endothelial function assessed by brachial artery flow mediated dilation | 2.5 hours post ingestion of juice |
| Blood pressure | Blood pressure recorded by automatic blood pressure machine |
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Inclusion Criteria:
• Stage 3-5 Chronic Kidney Disease
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Kinesiology and Applied Physiology, University of Delaware | Newark | Delaware | 19713 | United States |
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| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D002318 | Cardiovascular Diseases |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| Nitrate-depleted placebo | Dietary Supplement | Placebo |
|
| Change from pre-ingestion baseline to 2.5 hours post ingestion of juice |
| Arterial stiffness | Carotid to femoral pulse wave velocity assessed by tonometry | 2.5 hours post ingestion of juice |
| Pulse wave analysis | Central blood pressure and augmentation index assessed by oscillometry and radial tonometry | 2.5 hours post ingestion of juice |
| Peak aerobic capacity | Peak oxygen uptake (VO2 peak) during incremental cycling exercise to exhaustion | 2.5 hours post ingestion of juice |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |