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The main purpose of this study is to evaluate the effects of an acute dose of dietary nitrate in the form of beetroot juice on skeletal muscle blood flow in response to dynamic knee extension exercise in healthy older adults. All subjects will receive active (rich in dietary nitrate) or placebo (devoid of nitrate) supplementation.
Dietary nitrate (beetroot juice) is reduced to nitrite and nitric oxide within the digestive system of humans. Nitric oxide exerts potent vasodilator effects, which have been shown to reduce blood pressure and enhance exercise economy in humans. This pressure reducing effect may have implications within the regulation of blood flow during dynamic exercise in older adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nitrate Rich Beetroot Powder (nitrate) | Active Comparator | Dietary nitrate in the form of beetroot powder (10g) mixed in water will be administered acutely |
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| Placebo Beetroot Powder | Placebo Comparator | Beetroot powder devoid of nitrate (10g) will be mixed in water and administered acutely |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Super Beets | Dietary Supplement | Nitrate rich beetroot powder (10g) acutely |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Skeletal Muscle Blood Flow within the Leg via Doppler Ultrasound | Leg blood flow via Doppler ultrasound examined during dynamic knee extension exercise. Change in blood flow in response to dynamic knee exercise will be measured to examine the influence of dietary nitrate. | Pre and 2 hours post acute ingestion of dietary nitrate and placebo with at least 5 days of separation between visits. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical Education Building | Iowa City | Iowa | 52242 | United States |
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| ID | Term |
|---|---|
| D000783 | Aneurysm |
| D006940 | Hyperemia |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Beetroot powder | Dietary Supplement | Nitrate devoid beetroot powder (10g) acutely |
|