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The number of persons with hypertension is increasing and with it the number of related cardiovascular events and related functional or cognitive declines. While studies have suggested that physical activity, in particular, high-intensity interval training (HIIT), could be as efficient as the commonly used antihypertensive medications, no studies have actually compared their effects in the same population. This protocol will determine if HIIT is at least as efficient as hydrochlorothiazide in order to lower 24h-ambulatory blood pressure (BP) in prehypertensive older adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Intensity Interval Training (HIIT) | Experimental | For the twelve weeks of intervention, participants will have three training sessions per week. Each session will be done on a cycle ergometer and will last approximately 40 minutes. Participants will be supervised by certified kinesiologists and their training programs will be revised every four weeks. |
|
| HydroChloroThiazide | Active Comparator | For this group, participants have to take a diuretic (12,5 mg of Hydrochlorothiazide) daily prescribed by the doctor of this study, for twelve weeks. Participants should also maintain the same lifestyle habits that they had before the study. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 24h-Ambulatory Blood Pressure | Other | Effect of High Intensity Interval Training compared to Hydrochlorothiazide on ambulatory Blood Pressure. |
|
| Measure | Description | Time Frame |
|---|---|---|
| 24h-Ambulatory Blood Pressure | The 24-hour ambulatory measure of the blood pressure (AMBP) | At baseline and after twelve weeks of intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular evaluation | Maximum incremental cardiopulmonary exercise test (VO2MAX) | Before and after twelve weeks of intervention |
| Cognitive functions | Cognitive functions will be measured at rest with a pen-paper battery test by a neuropsychologist. The investigators will measure change of score to the cognitive tests. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anil Nigam, MD | Contact | 514-376-3330 | 4033 | anil.nigam@icm-mhi.org |
| Antoine Langeard, PhD | Contact | 514-374-1480 | 4369 | langeard.antoine@hotmail.fr |
| Name | Affiliation | Role |
|---|---|---|
| Anil Nigam, MD | Montreal Heart Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiovascular Prevention and Rehabilitation Center | Recruiting | Montreal | Quebec | H1T 1N6 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33484896 | Derived | Langeard A, Cloutier SO, Olmand M, Saillant K, Gagnon C, Gregoire CA, Fortier A, Lacroix M, Lalonge J, Gayda M, Besnier F, Gagnon D, Bherer L, Nigam A. High-intensity interval training vs. hydrochlorothiazide on blood pressure, cardiovascular health and cognition: Protocol of a non-inferiority trial. Contemp Clin Trials. 2021 Mar;102:106286. doi: 10.1016/j.cct.2021.106286. Epub 2021 Jan 20. |
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| ID | Term |
|---|---|
| D000075222 | Essential Hypertension |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D016059 | Range of Motion, Articular |
| ID | Term |
|---|---|
| D010808 | Physical Examination |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D009142 | Musculoskeletal Physiological Phenomena |
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|
| Before and after twelve weeks of intervention |
| Flow Mediated Dilatation (FMD) | Percentage of dilatation of the brachial artery | Before and after twelve weeks of intervention |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |