Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Ministry of Research and Higher Education of Republic Indonesia | UNKNOWN |
| United States Agency for International Development (USAID) | FED |
Not provided
Not provided
Not provided
Not provided
This study is part of the East Jakarta Cohort Study to assess the current micronutrient status of the mothers and their children. The study also includes the assessment of genotyping of MTHFR 677C-->T of the mother and DNA methylation of IGF2 gene of the children.
The initial study recruited 315 mothers in the public health centre and one district hospital in East Jakarta. The follow-up study is able to re-visit the 127 of them. This also includes 127 peers of the subject that lives in the same neighbourhood. The design of the study is case-cohort design, part study of the existing cohort. The assessment of the follow-up study includes the mother and the children born in the initial study. Anthropometric measurement, socioeconomic data from a structured questionnaire, biomarker assessment, blood pressure were obtained from the subjects.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| East Jakarta Cohort Study | One group included in the study was originated from mothers who participated in the first data collection pregnancy. The follow-up study included mothers and their children born as the subject in the follow-up in the study. This study also includes peer of the subjects that lived in the same neighbourhood since the first cohort study and have children in the same age with cohort participant |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Serum folic acid status | The measurement of serum folic acid status is using LC-MS/MS | December 2018 - March 2019 |
| Genotyping MTHFR 677C-->T | The assessment of MTHFR 677C-->T using Real Time PCR | December 2018 - March 2019 |
| DNA methylation of IGF2 gene | DNA methylation of IGF2 gene using pyrosequencing method | December 2018 - March 2019 |
| Measure | Description | Time Frame |
|---|---|---|
| Serum Homocysteine | The measurement of serum homocysteine using Electrochemiluminescen | December 2018-March 2019 |
| Serum Adiponectin | The measurement of serum adiponection using electrochemiluminescence |
| Measure | Description | Time Frame |
|---|---|---|
| Nutritional status assessment | Using antrhopometric measurement, using SECA for weight measurement, Shorrboard for height and standardized plastic tape for mid upper arm circumference. | September 2018-December 2018 |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
In 2014, the pregnant mothers in 10 public health centre and one sub-district hospital in East Jakarta were recruited in the study. They were in the third trimester gestation period, receive iron-folic acid supplementation and ANC. In 2018, the repeated collection was conducted to collect follow-up data. We also include peer of the subjects that lived in the same neighbourhood since the first cohort study and have children in the same age with cohort participant
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Rina RA Agustina, Doctoral | Indonesia University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitas Indonesia | Jakarta | DKI Jakarta | 10430 | Indonesia |
Not provided
| Label | URL |
|---|---|
| The maternal folic acid supplementation results strengthen the link between folic acid supplementation during later pregnancy and epigenetic changes and identify a novel mechanism for regulation of ZFP57. | View source |
Not provided
I will not share the IPD of the subject participated due to consent issue
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
DNA isolated from the whole blood using standardized equipment and procedure of blood taking.
DNA obtained from mother-children of the participant in the study
| December 2018-March 2019 |
| Blood pressure | The blood pressure measurement using semi automatic device (Omron HBP1300) | December 2018-March 2019 |
| ID | Term |
|---|---|
| D005494 | Folic Acid Deficiency |
| ID | Term |
|---|---|
| D014804 | Vitamin B Deficiency |
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided