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a) Compare between Nonabsorbable Polymeric Clips and Endoloop ligatures regarding:
Laparoscopic appendectomy is gradually evolving as the 'gold standard' in the treatment of acute appendicitis, especially in the obese, elderly, and in cases where the diagnosis is uncertain . There are clear benefits with the laparoscopic approach in terms of decreased pain and faster recovery than the open approach . However, disadvantages like a higher incidence of intra-abdominal collection, longer operating time, and higher costs have been documented. These may be dependent on the technique of appendicular stump closure. Therefore, the technique for appendiceal stump closure is crucial in laparoscopic appendectomy.
Laparoscopic appendectomy was first described by Semm in 1983 and is currently preferred approach for an appendectomy for many surgeons. Numerous methods of stump closure have been used, like intracorporeal suturing of the stump endoloop application, endostapler application LigaSure customized titanium clip application, and, more recently, using nonabsorbable plastic clips . Many of these techniques are either time consuming or expensive, or not available universally.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| endoloop ligation | Active Comparator | securing appendicular base with endoloops |
|
| non absorbable polymeric clips | Active Comparator | securing appendicular base with non absorbable polymeric clips |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| polymeric non absorbable clips | Device | a method to secure appendicular stump |
|
| Measure | Description | Time Frame |
|---|---|---|
| Operative time | Is there difference in the overall operating time between the two cohorts | intraoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Complications | Is there a difference in the rate of intraoperative and postoperative complications | 30 days |
| Length of hospital stay (postoperative) | Is there a significant difference in the length of postoperative stay between the two cohorts |
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Inclusion Criteria:
Exclusion Criteria:
• Intraoperative decision to convert to open appendicectomy
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| mohamed ashraf, master | Contact | 01060624371 | akhel93@yahoo.com | |
| Morssy mohamed, professor | Contact | 01006234545 | morssy.mohamed@med.au.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Hesham Ali, professor | Assiut university faculty of medicine | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31446471 | Background | Kliuchanok K, Kessler W, Partecke I, Walschus U, Schulze T, Heidecke CD, Patrzyk M. A comparison of non-absorbable polymeric clips and staplers for laparoscopic appendiceal stump closure: analysis of 618 adult patients. Langenbecks Arch Surg. 2019 Sep;404(6):711-716. doi: 10.1007/s00423-019-01814-w. Epub 2019 Aug 24. | |
| 29543058 |
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| ID | Term |
|---|---|
| D001064 | Appendicitis |
| ID | Term |
|---|---|
| D059413 | Intraabdominal Infections |
| D007239 | Infections |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
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| endoloops | Other | a method to secure appendicular stump |
|
| Up to 14 days |
| Readmission to hospital | Is there a difference in the thirty day readmission rates between the two cohorts | 30 days |
| Time of Application | Time of application of endoloop, polymeric clip measured from introducing of instruments to cutting the base of appendix | 120 min |
| Wilson M, Maniam P, Ibrahim A, Makaram N, Knight SR, Patil P. Polymeric clips are a quicker and cheaper alternative to endoscopic ligatures for securing the appendiceal stump during laparoscopic appendicectomy. Ann R Coll Surg Engl. 2018 Jul;100(6):454-458. doi: 10.1308/rcsann.2018.0036. Epub 2018 Mar 15. |
| 29190038 | Background | Mannu GS, Sudul MK, Bettencourt-Silva JH, Cumber E, Li F, Clark AB, Loke YK. Closure methods of the appendix stump for complications during laparoscopic appendectomy. Cochrane Database Syst Rev. 2017 Nov 13;11(11):CD006437. doi: 10.1002/14651858.CD006437.pub3. |
| 29098432 | Background | Delibegovic S, Mehmedovic Z. The influence of the different forms of appendix base closure on patient outcome in laparoscopic appendectomy: a randomized trial. Surg Endosc. 2018 May;32(5):2295-2299. doi: 10.1007/s00464-017-5924-z. Epub 2017 Nov 2. |
| 27996377 | Background | Pogorelic Z, Kostovski B, Jeroncic A, Susnjar T, Mrklic I, Jukic M, Juric I. A Comparison of Endoloop Ligatures and Nonabsorbable Polymeric Clips for the Closure of the Appendicular Stump During Laparoscopic Appendectomy in Children. J Laparoendosc Adv Surg Tech A. 2017 Jun;27(6):645-650. doi: 10.1089/lap.2016.0433. Epub 2016 Dec 20. |
| D004066 |
| Digestive System Diseases |
| D002429 | Cecal Diseases |
| D007410 | Intestinal Diseases |