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The use of antibiotics causes profound changes in the microbiota. However, the magnitude of the effect of intrapartum and early-life antibiotics on the breast milk and the infant oral and intestinal microbiota, and whether effects are only short-term or persist long-term remain uncertain and will be determined in this study.
In this prospective cohort study, the investigators will determine the effect of (i) intrapartum antibiotics on the composition of the breast milk, and the infant oral and intestinal microbiota and antibiotic exposure in the first year of life on the composition of the infant intestinal microbiota (including the development and persistence of antibiotic resistance) and (ii) the association of this disruption with adverse health outcomes. (iii) The investigators will also determine the association between the maternal intestinal microbiota, the breast milk microbiota and the infant oral and intestinal microbiota.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | No intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Antibiotic-induced disruption of breast milk microbiota | Composition of breast milk microbiota at birth and when infants are 7 days, 1, 2, 4, 6, 12 and 24 months of age. | 2 years |
| Antibiotic-Induced disruption the infant stool microbiota | Composition of infant intestinal microbiota at birth and when infants are 7 days, 1, 2, 4, 6, 12 and 24 months of age. | 2 years |
| Maternal to infant microbiota transfer | Similarities in the composition of the maternal intestinal, the breast milk microbiota and the infant intestinal microbiota, at 38 weeks of pregnancy, at birth and when infants are 7 days, 1, 2, 4 and 6 months of age. | 2 years |
| The composition of the intestinal microbiota and adverse health outcomes | Abundance of certain microbes in the intestinal microbiota and number of episodes of lower respiratory tract infections until 2 years of age | 2 years |
| The composition of the intestinal microbiota and adverse health outcomes | Abundance of certain microbes in the intestinal microbiota and number of episodes of acute otitis media episodes until 2 years of age | 2 years |
| The composition of the intestinal microbiota and adverse health outcomes | Abundance of certain microbes in the intestinal microbiota and prevalence of allergic sensitisation (positive skin prick test) at 1 and 2 years of age | 2 years |
| The composition of the intestinal microbiota and adverse health outcomes |
| Measure | Description | Time Frame |
|---|---|---|
| Antibiotic-induced disruption of breast milk microbiota | Prevalence of antibiotic resistance genes within the breast milk microbiota at birth and when infants are 7 days, 1, 2, 4, 6, 12 and 24 months of age. | 2 years |
| Antibiotic-Induced disruption the infant stool microbiota |
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Inclusion Criteria:
Exclusion Criteria:
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Women who give birth at the Hôpital fribourgeois (HFR) in Fribourg, Switzerland and their infants.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Petra Zimmermann, MD, PhD | Contact | +413063542 | petra.zimmermann@h-fr.ch |
| Name | Affiliation | Role |
|---|---|---|
| Petra Zimmermann, MD, PhD | Hopital Cantonal de Fribourg, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital cantonal Fribourg | Recruiting | Fribourg | 1700 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32580987 | Derived | Volery M, Scherz V, Jakob W, Bandeira D, Deggim-Messmer V, Lauber-Biason A, Wildhaber J, Falquet L, Curtis N, Zimmermann P. Study protocol for the ABERRANT study: antibiotic-induced disruption of the maternal and infant microbiome and adverse health outcomes - a prospective cohort study among children born at term. BMJ Open. 2020 Jun 23;10(6):e036275. doi: 10.1136/bmjopen-2019-036275. |
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Stool, oral swabs, breast milk, blood
Abundance of certain microbes in the intestinal microbiota and weight (in kg) at 1 and 2 years of age |
| 2 years |
Prevalence of antibiotic resistance genes within the intestinal microbiota at birth and when infants are 7 days, 1, 2, 4, 6, 12 and 24 months of age. |
| 2 years |
| Introduction of different foods affects the composition of the intestinal microbiota | Age (in days) when a new food item was introduced and composition of infant intestinal microbiota when infants are 1, 2, 4, 6, 12 and 24 months of age. | 2 years |
| Administration of oxygen affects the composition of the intestinal microbiota in infants | Number of days of oxygen and composition of infant intestinal microbiota when infants are 7 days, 1, 2, 4, 6, 12 and 24 months of age. | 2 years |
| Administration of antacids affect the composition of the infant intestinal microbiota | Number of days antacids were administered and composition of infant intestinal microbiota at birth and when infants are 7 days, 1, 2, 4, 6, 12 and 24 months of age. | 2 years |