Clinical Translational Science Institute (CTSI) Brain HQ Modules vs. Active Controls for Elderly Survivors of ICU

Structured Cognitive Therapy to Improve Neurocognitive Dysfunction in Older Intensive Care Unit Sepsis Survivors

The purpose of this project is to test whether an online cognitive rehabilitation program or online thinking exercises helps improve memory and thinking in elderly patients who survive a severe infection.

Currently, over 50% of patients are estimated to develop an Alzheimer's like disease following their hospitalization. This means they might have trouble remembering simple things or doing simple tasks. This can make returning to normal life difficult. This project will test whether online thinking exercises can help speed up patient's recovery.

Inclusion Criteria:

1. Admitted to the Intensive Care Unit (ICU) at Froedtert Memorial Lutheran Hospital (FMLH)
2. Diagnosis of Sepsis
3. Age 65 years or older
4. Required mechanical ventilation or vasopressor therapy while in the ICU
5. Had delirium while in the ICU

Exclusion Criteria:

1. Non-English Speaking
2. Severe Dementia that would interfere with the ability to participate in the study activities
3. Prior or current structural neurological injury that would confound study results
4. Inability to communicate for any reason
5. Current chemotherapy or radiation treatment
6. Recent history of substance abuse
7. Life expectancy < 6 months
8. Planned discharge to long term acute care facility or nursing home
9. Lack reliable access to the internet either through a computer or smart device