Single-dose Vaginal Dinoprostone and Hysterectomy

Effect of a Single Preoperative Dose of Vaginal Dinoprostone on Intraoperative Blood Loss During Abdominal Hysterectomy:a Randomized Controlled Trial

In this study, we will assess the efficacy of dinoprostone in minimizing blood loss during hysterectomy when used as a single preoperative dose via the vaginal route. The reduction of blood flow may be due to the combined effect of myometrial contraction and vasoconstrictive effect

Inclusion Criteria:

• • Patients presenting for hysterectomy for any benign indication including uterine fibroids.

  • Age ≥ 18 years
  • Pre-operative hemoglobin >8 g/dl
  • Willing to have dinoprostone or a placebo prior to hysterectomy
  • Ability to understand and the willingness to sign a written informed consent.

Exclusion Criteria:

• • Patients with known or suspected endometrial/ovarian/cervical cancer.

  • Patients undergoing hysterectomy for endometrial hyperplasia or cervical dysplasia.
  • Patients currently undergoing treatment for any type of cancer.
  • Patients with known bleeding/clotting disorders or a history of thromboembolism (including deep venous thrombosis or pulmonary embolism)
  • History of allergic reactions to dinoprostone.