Preoperative Vaginal Dinoprostone Versus Misoprostone in Abdominal Myomectomy

Preoperative Vaginal Dinoprostone Versus Misoprostone to Decrease Bleeding During Abdominal Myomectomy

Aim and objectives; To compare the efficacy of preoperative administration of dinoprostone 20 mg versus 400 ug misoprostol vaginally in decreasing the amount of bleeding during abdominal myomectomy

Background; Myomectomy is a curative interventional option for many kinds of uterine fibroids, but considerable intraoperative haemorrhage and the necessities for transfusions of blood are still the main challenge for abdomen myomectomy.

Aim and objectives; To compare the efficacy of preoperative administration of dinoprostone 20 mg versus 400 ug misoprostol vaginally in decreasing the amount of bleeding during abdominal myomectomy Subjects and methods; This was a prospective randomized double-blind controlled study that included 90 patients complaining of uterine myoma and indicated for myomectomy selected from the outpatient clinic at Beni-suef university hospital

Inclusion Criteria:

• Age 30-50 years
• all cases with uterine fibroid not responding to medical treatment and indicated for myomectomy.

Exclusion Criteria:

• contraindications to dinoprostone or misoprostol,
• active PID,
• history of pelvic/ ovarian endometriosis,
• females who had pre-operative mifepristone, GnRH analog or orally contraception drugs, earlier myomectomy.