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In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with grown-up congenital heart disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Supplemental oxygen | Experimental | Supplemental oxygen will be applied via a mask during CPET |
|
| Sham room air | Sham Comparator | Room air will be applied similarly to oxygen |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxygen application | Procedure | Oxygen application Supplemental oxygen via mask |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Work Rate (Watt) | Maximal Work Rate (Wmax) measured during cardiopulmonary exercise test oxygen vs. room air | 1 day |
| Endurance Time (s) Endurance Time (s) Endurance Time (s) | Endurance (s) with 75% Wmax measured during cardiopulmonary exercise test oxygen vs. room air | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Peak Oxygen uptake | measured during cardiopulmonary exercise test oxygen vs. room air | 1 day |
| Respiratory Exchange ratio | measured during cardiopulmonary exercise test oxygen vs. room air |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Zurich, Division of Pneumology | Zurich | , 8091 | Switzerland |
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| Sham room air |
| Procedure |
Room air applied via mask |
|
| 1 day |
| Changes in arterial blood parameters | measured during cardiopulmonary exercise test oxygen vs. room air | 1 day |
| muscle tissue oxygen | Oxygen saturation in the muscle measured during cardiopulmonary exercise test oxygen vs. room air with near infrared spectroscopy | 1 day |
| cerebral tissue oxygen | Oxygen saturation in the brain measured during cardiopulmonary exercise test oxygen vs. room air with near infrared spectroscopy | 1 day |