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In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Supplemental oxygen | Experimental | Supplemental oxygen will be applied via a mask during CPET |
|
| Sham room air | Placebo Comparator | Room air will be applied similarly to oxygen |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Supplemental oxygen via a mask | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Watt | 1 day | |
| exercise time | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Peak oxygen uptake | 1 day | |
| Respiratory exchange ratio | 1 day | |
| ventilatory equivalent of carbon dioxide (VE/VCO2) slope |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Silvia Ulrich Somaini, MD | University Hospital Zurich, Division of Pneumology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Zurich, Division of Pneumology | Zurich | Canton of Zurich | 8091 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28329240 | Derived | Ulrich S, Hasler ED, Saxer S, Furian M, Muller-Mottet S, Keusch S, Bloch KE. Effect of breathing oxygen-enriched air on exercise performance in patients with precapillary pulmonary hypertension: randomized, sham-controlled cross-over trial. Eur Heart J. 2017 Apr 14;38(15):1159-1168. doi: 10.1093/eurheartj/ehx099. |
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| 1 day |
| end-tidal pressures of carbon dioxide (PET CO2) | 1 day |
| Changes in arterial blood parameters | 1 day |