Effects of Green Propolis Extract (EPP-AF) on Inflammation in Hemodialysis Patients.

Effects of Green Propolis Extract (EPP-AF) on Inflammation in Hemodialysis Patients: a Randomized Cross-over Trial.

End-stage chronic kidney disease is associated with the condition of chronic inflammation. Patients on hemodialysis are known to be predisposed to several factors that predispose to inflammation: dialysis membranes, central venous catheters, oxidative stress, fluid overload, sodium overload, uraemic toxins. Propolis, a natural resin produced by bees from plant materials, has anti-inflammatory, immunomodulatory, and anti-oxidant properties. The aim of this study was to evaluate the impact of Brazilian green propolis extract on inflammation in hemodialysis patients.

Randomized open-label cross-over trial to investigate impact of Brazilian green propolis extract on inflammation in hemodialysis patients.

Inclusion Criteria:

• Age over 18 years;
• Male or female on hemodialysis for at least 1 month.

Exclusion Criteria:

• Pregnant Woman;
• Carriers of active neoplasms;
• Patients undergoing kidney transplantation during the study;
• Infection during the study;
• Patients who underwent parathyroidectomy during the study;
• Patient using immunosuppressive drugs;
• Allergy to propolis or any of its components;