Injectable Platelet Rich Fibrin With Non Surgical Periodontal Therapy

Comparative Evaluation of Local Injectable Platelet Rich Fibrin and Hyaluronic Acid as Adjunctive to Non Surgical Periodontal Therapy: a Randomized Placebo Controlled Clinical Trial

Clinical evaluation of local subgingival application of injectable platelet-rich fibrin ( i-PRF ) for chronic periodntitis as adjunctive to non surgical therapy and compare it with hyaluronic acid.

120 periodontal patients will receive a scaling and root planing ( non surgical periodontal therapy). Equal number of patients will receive subgingival application of i-PRF, hyaluronic acid or placebo gel as the adjunction to non surgical therapy.

The aim of the study is to evaluate and compare the clinical efficacy of subgingival application of i-PRF and hyaluronic acid gel as adjunctive to non-surgical periodontal therapy. 120 periodontal patients will receive traditional mechanical supra and subgingival scaling and root planing. Patients were randomly allocated in three groups. Group 1, 2 and 3 will receive subginigval application of placebo, hyaluronic acid gel and i prf respectively. Clinical parameters will be evaluated: plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), gingival recession (GR). Clinical measurements will be performed at baseline, 1 month and at 3 months.

Inclusion Criteria:

• Patients are in general good health.
• Patients having minimum of 20 permanent teeth.
• They have not taken medication known to interfere with periodontal tissue health or healing in the preceding 6 months.
• Presence of periodontal pockets (≥5 mm) and clinicala ttachment level > 5 mm.

Exclusion Criteria:

• Immunosuppressive systemic diseases (like cancer, AIDS, diabetes etc.)
• Clotting and Hematological disorders
• Patients with grade III mobility.
• Patients with smoking and alcohol consuming habit.
• Pregnant and lactating female.
• Medications influence on the gingival and periodontal tissues (like calcium channel blockers, or Long-term steroid use)
• The teeth with poor filling and ill fitted restorations