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Since the absorption of clopidogrel through the gastrointestinal tract is limited, we want to examine whether adding clopidogrel by chewing will overcome the limited gastrointestinal absorption, and hence will improve the prevention of platelet aggregation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| clopidogrel by chewing | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| clopidogrel by chewing | Drug | 600 mg clopidogrel by chewing |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Platelet aggregation and bleeding events | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sheba Medical Center, Cardiac Institute | Recruiting | Tel Litwinsky | Tel Hashomer | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12796140 | Background | Gurbel PA, Bliden KP, Hiatt BL, O'Connor CM. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation. 2003 Jun 17;107(23):2908-13. doi: 10.1161/01.CIR.0000072771.11429.83. Epub 2003 Jun 9. | |
| 15184279 | Background | Matetzky S, Shenkman B, Guetta V, Shechter M, Beinart R, Goldenberg I, Novikov I, Pres H, Savion N, Varon D, Hod H. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation. 2004 Jun 29;109(25):3171-5. doi: 10.1161/01.CIR.0000130846.46168.03. Epub 2004 Jun 7. |
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| Placebo |
| Drug |
Placebo p.o |
|
| Sheba_medical_center | Not yet recruiting | Ramat Gan | Israel |
|