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efficacy of adding azithromycin to cephalosporin before cesarean delivery
efficacy of adding azithromycin to cephalosporin for the prophylaxis against infectious morbidity following cesarean delivery in high risk women
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| cephalosporin arm | Active Comparator | 72 women will receive single antibiotic chemotheraby first generation cephalosporin (cefazolin) 2 gm iv within 30 minutes before skin incision |
|
| cephalosporin +azithromycin arm | Active Comparator | 72 women will receive combined antibiotic chemotherapy azithromycin (Azrolid) 1 gm single oral dose 2 hours before cesarean delivery + cephalosporin(Cefazolin) 2 gm iv within 30 minutes before skin incision |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cephalosporin | Drug | 72 women will receive single antibiotic chemotherapy(Cefazolin) 2 gm iv within 30 minutes before skin incision |
|
| Measure | Description | Time Frame |
|---|---|---|
| % of women with wound infection | superficial and deep surgical site wound infection will be looked for by laboratory confirmation | after 14 days post cesarean delivery |
| Measure | Description | Time Frame |
|---|---|---|
| % of women with postpartum endometritis | fever, abdominal pain , uterine tenderness will be looked for | after 14 days post cesarean delivery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Reda Mokhtar, MD | AinShams university ,egypt el abbasia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams maternity hospital | Cairo | Egypt |
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| ID | Term |
|---|---|
| D002511 | Cephalosporins |
| D017963 | Azithromycin |
| ID | Term |
|---|---|
| D047090 | beta-Lactams |
| D007769 | Lactams |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013843 |
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| Azithromycin Tablets | Drug | 72 women will receive combined antibiotic chemotherapy azithromycin(Azrolid) 1 gm single oral dose 2 hours before cesarean delivery +cephalosporin(Cefazolin) 2 gm iv within 30 minutes before skin incision |
|
| Thiazines |
| D013457 | Sulfur Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D004917 | Erythromycin |
| D018942 | Macrolides |
| D061065 | Polyketides |
| D007783 | Lactones |