The Pharmacokinetics of Azithromycin Prophylaxis for Cesarean Delivery

The Pharmacokinetics of Azithromycin Prophylaxis for Cesarean Delivery

PKAZ is a single institution study designed to evaluate the optimal dosing parameters for azithromycin for pre-surgical cesarean prophylaxis.

Hypothesis: Pre-operative administration of azithromycin results in maternal and neonatal tissue concentrations that adequately treat microbes commonly involved in post-cesarean infections.

Inclusion Criteria:

• Women 19 years and older
• Term (37 weeks and greater)
• Singleton gestation
• Scheduled cesarean section
• Non-laboring
• Intact membranes

Exclusion Criteria:

• < 19 years of age
• Preterm (< 37 weeks)
• Multifetal gestation
• Laboring or ruptured membranes
• Known fetal anomaly
• Oligo- or polyhydramnios
• Macrolide allergy
• Macrolide exposure within 2 weeks
• Medical co-morbidities
• Hepatic or renal impairment
• Taking medications that prolong the QT interval
• Currently taking nelfinavir, efavirenz, or flucanozole
• Structural heart defects or arrythmia