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| ID | Type | Description | Link |
|---|---|---|---|
| KlinStrucMed program | Other Grant/Funding Number | Else Kröner-Fresenius-Stiftung |
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| Name | Class |
|---|---|
| Institut National de la Santé Et de la Recherche Médicale, France | OTHER_GOV |
| F-CRIN | UNKNOWN |
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Objectives: The aim of this study is to determine whether growth differentiation factor-15 (GDF15) and circulating neprilysin (cNEP) improve the diagnosis of congestive heart failure (HF) in patients on dialysis.
Background: Dialysis patients are at increased risk of HF. However, diagnostic utility of NT-proBNP as a biomarker is decreased in patients on dialysis. GDF15 and cNEP are biomarkers of distinct mechanisms that may contribute to HF pathophysiology in such cohorts.
Methods: We compare circulating concentrations of NT-proBNP, GDF15, and cNEP along with NEP activity in patients on chronic dialysis without and with HF, as diagnosed by clinical parameters and post-dialysis echocardiography. We use correlation, linear and logistic regression as well as receiver operating characteristic (ROC) analyses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HF (heart failure) | Patients with end stage renal disease requiring dialysis with reduced or preserved ejection fraction. |
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| Control | Patients with end stage renal disease requiring dialysis without HF. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diagnostic biomarker study | Diagnostic Test | Comparing circulating concentrations of NT-proBNP, GDF15, and neprilysin (NEP) along with NEP activity in patients with and without HF, as diagnosed by clinical parameters and post-dialysis echocardiography. |
| Measure | Description | Time Frame |
|---|---|---|
| HF diagnosis | Diagnosis of HF | Baseline (at study entry (diagnostic biomarker study)) |
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Inclusion Criteria:
Exclusion Criteria:
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End stage renal disease (ESRD) patients on chronic dialysis.
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| Name | Affiliation | Role |
|---|---|---|
| Michael S Balzer, MD | Hannover Medical School | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inserm Umr S-942 | Paris | France | ||||
| Hannover Medical School |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D007676 | Kidney Failure, Chronic |
| D051436 | Renal Insufficiency, Chronic |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
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Plasma, serum, peritoneal dialysate.
| Hanover |
| 30175 |
| Germany |
| D014570 |
| Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |