Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Erasme University Hospital | OTHER |
Not provided
Not provided
Not provided
Not provided
To demonstrate the effect of non invasive vagus nerve (VNS) stimulation on heart rate variability and MSNA signal.
First part: Assessment of the muscle sympathetic nerve activity (MSNA) at baseline using microneurography performed on the superficial peroneal nerve.
Second part: Acquisition of the MSNA signal during non-invasive VNS and apnea. Non-invasive VNS is performed using several frequencies of stimulation. Maximal and voluntaries apnea are performed at the end of the expiration.
Continuous recording of the following parameters:
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stimulation protocol | Active Comparator | Each subject will be blinded and underwent 3 phases of stimulation (actives (2) and sham (1) comparators) in a randomized order . |
|
| Sham stimulation protocol | Sham Comparator | Each subject will be blinded and underwent 3 phases of stimulation (actives (2) and sham (1) comparators) in a randomized order. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Modulation of muscle sympathetic nerve activity | Other | Assessment of muscle sympathetic nerve signal and exposition to external non invasive modulation. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate variability modulation | Modulation of heart rate variability assessed through analysis of MSNA signal | 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Non-invasive vagus nerve stimulation | Modulation of parasympathetic tone based on two different frequencies stimulation | 4hours |
| Profile of response for MSNA | To describe positive and negative patterns of MSNA response |
| Measure | Description | Time Frame |
|---|---|---|
| Profile of response of MSNA during prolonged breath hold | Modulation of MSNA activity during repetitive prolonged breath hold | 4hours |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anaïs Gauthey, MD | Contact | 027682888 | 0032 | anais.gauthey@uclouvain.be |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Erasme University Hospital | Recruiting | Brussels | 1070 | Belgium |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Randomized, controlled, double-blind, cross-over study
Not provided
Not provided
Investigators are double-blinded for both experimental procedures and data analyzes.
Volunteers are blinded to the site of stimulation.
| 4 hours |