This study will use a multi-center, prospective design, with a "Real World Study" model, to include 200 patients with nephrotic syndrome. based on the Population Pharmacokinetics (PPK) model, it will study genotype and clinical factors in patients with nephrotic syndrome, to explore the Pharmacokinetics/ Pharmacodynamics (PK/PD) relationship of Tacrolimus in patients with nephrotic syndrome, and develop an optimal medication regimen.

Inclusion Criteria:

• （1）Patients with Nephrotic Syndrome：

  1. Proteinuria greater than 3.5 g/24 hour
  2. Serum albumin <30 g/l
  3. Clinical evidence of peripheral oedema
  4. Hyperlipidemia 1) and 2) are necessary for diagnosis.

• （2）18-75years old（include 75），gender is not limited；

• （3）Voluntary signing informed consent。

Exclusion Criteria:

• （1）Secondary nephrotic syndrome；
• （2）Allergic to Tacrolimus or other unsuitable use of Tacrolimus；
• （3）With other immunosuppressive agents such as cyclosporin A, cyclophosphamide, mycophenolate mofetil, leflunomide, tripterygium wilfordii (hormone is not restricted)；
• （4）Severe liver dysfunction (transaminase > 3 ULN, or bilirubin > 3 ULN)；
• （5）Severe renal insufficiency（eGFR<30 ml/min/1.73m2）
• （6）Joined other clinical trials within 1 month；
• （7）Missing clinical data；
• （8）Pregnancy, lactation or planning for pregnancy within 12 months；
• （9）Researchers believe that patients who are not suitable for this clinical trial。

Patients with Nephrotic Syndrome are suit for use of Tacrolimus.

We welcomes researchers interested in collaboration. We request a short research proposal including information on the background, research questions and methods, timetable and budget, and authorship. For more information please contact the principal investigator.