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The implementation of nutritional strategies targeting several variables at once could benefit patients with cirrhosis. Non-alcoholic beer has different compounds derived from hops that exert antioxidant, anti-inflammatory and nutritional properties. The aim of this study is to evaluate the effect of diet + exercise and non-alcoholic beer on nutritional status, endothelial function and quality of life in patients with cirrhosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Active Comparator | personalized nutritional therapy + aerobic exercise |
|
| Non-alcoholic Beer | Active Comparator | non-alcoholic beer + personalized nutritional therapy + aerobic exercise |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-alcoholic beer | Dietary Supplement | Treatment consisted of 330ml non-alcoholic beer per day, plus an individualized dietary program and an exercise program with a pedometer-based bracelet to reach at least 5000 steps/day during 2 + 8 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Nutritional status | improvement in impedance-derived phase angle (PhA) | 8 weeks |
| Endothelial function | improvement in flow-mediated dilation (brachial artery) | 8 weeks |
| Endothelial dysfunction | improvement in serum markers of endothelial function (v.gr. nitric oxide, NO; prostacyclin, PGI2, etc.) | 8 weeks |
| Quality of life questionnaire | Improvement in quality of life questionnaire CLDQ (chronic liver disease questionnaire) | 8 weeks |
| Changes in the heterogeneity of gut Microbiota | Changes in the heterogeneity of fecal microbiota in terms of bacterial diversity will be assessed | 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ricardo U. Macías-Rodríguez, M.D., Ph.D. | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Study Director |
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| ID | Term |
|---|---|
| D005355 | Fibrosis |
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
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| control | Other | Treatment consisted of 330ml of water, plus an individualized dietary program and an exercise program with a pedometer-based bracelet to reach at least 5000 steps/day during 2 + 8 weeks. |
|
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D012816 | Signs and Symptoms |