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This study is aimed at evaluating patient work of breathing and tidal volumes with three methods of oxygenation: standard oxygen, high-flow oxygen therapy and non-invasive ventilation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Other | Standard oxygen - High-Flow Nasal Oxygen - Non-invasive ventilation - Standard Oxygen (20 minutes for each condition) |
|
| Group 2 | Other | Standard oxygen - Non-invasive ventilation - High-Flow Nasal Oxygen - Standard Oxygen (20 minutes for each condition) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High-Flow Nasal Oxygen / Non-invasive ventilation / Standard oxygen | Device | Device High Flow Nasal Oxygen: gas flow of 50L:Min and FiO2 adjusted to obtain SpO2>= 92% Device NIV: Pressure-support level to achieve an expired tidal volume between 6 and 8 ml/kg and PEEP level of 5 cmH2O and FiO2 adjusted for SpO2>= 92% |
| Measure | Description | Time Frame |
|---|---|---|
| Patient respiratory effort and tidal volume (Vt) | Swing of oesophageal pressure and pressure-Time product measured by a nasogastric pressure sensor tidal Volume estimated by electric impedance tomography | 1h20 |
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory parameters | respiratory rate (FR bt/min) | "Time 0","Time 20 min", "Time 40 min", "Time 60 min", "Time 120 min" |
| Respiratory parameters | saturation (SpO2 in %) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Arnaud W. THILLE, PUPH | Contact | +33 5 49 44 38 54 | arnaud.thille@chu-poitiers.fr | |
| Céline DELETAGE | Contact | celine.deletage@chu-poitiers.fr |
| Name | Affiliation | Role |
|---|---|---|
| Arnaud W. THILLE, PUPH | Medecine intensive reanimation CHU Poitiers | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Poitiers | Recruiting | Poitiers | 86000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40341100 | Derived | Arrive F, Le Pape S, Bruhn A, Pepin Lehalleur A, Beuvon C, Tuffet S, Etien E, Rambault L, Frat JP, Coudroy R, Thille AW. Physiological comparison of noninvasive ventilation and high-flow nasal oxygen on inspiratory efforts and tidal volumes after extubation: a randomized crossover trial. Crit Care. 2025 May 8;29(1):185. doi: 10.1186/s13054-025-05366-y. | |
| 33661521 |
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|
| "Time 0","Time 20 min", "Time 40 min", "Time 60 min", "Time 120 min" |
| Respiratory parameters | transcutaneous CO2 pressure (PCO2 in mm Hg) | "Time 0","Time 20 min", "Time 40 min", "Time 60 min", "Time 120 min" |
| Respiratory parameters | transpulmonary pressure (cm H2O) | "Time 0","Time 20 min", "Time 40 min", "Time 60 min", "Time 120 min" |
| Hemodynamic parameters | Systolic arterial pressure (PAS in mmHg), Diastolic arterial pressure (PAD in mmHg) | "Time 0","Time 20 min", "Time 40 min", "Time 60 min", "Time 120 min" |
| Comfort evaluation | comfort evaluation with an visual evaluation scale graduate 0 cm (No discomfort) to 10 cm (maximal discomfort) | "Time 0","Time 20 min", "Time 40 min", "Time 60 min", "Time 120 min" |
| Intensive reanimation | Recruiting | Poitiers | 86000 | France |
|
| Lewis SR, Baker PE, Parker R, Smith AF. High-flow nasal cannulae for respiratory support in adult intensive care patients. Cochrane Database Syst Rev. 2021 Mar 4;3(3):CD010172. doi: 10.1002/14651858.CD010172.pub3. |
| ID | Term |
|---|---|
| D063087 | Noninvasive Ventilation |
| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012138 | Respiratory Therapy |
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