This is a cross-sectional, retrospective clinical observation study focusing on the incidence and influencing factors of nocturnal symptoms in patients with Parkinson's disease.

This study was a cross-sectional, retrospective clinical observation study investigating the incidence and influencing factors of nocturnal symptoms in patients with Parkinson's disease through the Parkinson's disease sleep-related scale. At the same time, the effects of nocturnal symptoms on the quality of life of patients with Parkinson's disease were studied. About 1,500 Parkinson's patients will be recruited into the study who come from Shanghai, China.

Inclusion Criteria:

1. Parkinson's disease patients diagnosed according to the diagnostic criteria of MDS
2. Signing informed consent

Exclusion Criteria:

1. clinically suspected Parkinson's disease, has not been diagnosed;
2. suspected or diagnosed as secondary Parkinson's syndrome (vascular, drug, traumatic, encephalitis, toxic, etc.);
3. suspected or diagnosed as atypical Parkinson's syndrome (progressive supranuclear palsy, multiple system atrophy, cortical basal ganglia degeneration, etc.);
4. There is a clear history of stroke, moderate to severe traumatic brain injury, hydrocephalus, brain surgery or history of brain tumors;
5. severe cognitive impairment or psychiatric symptoms;
6. Can not cooperate with the completion of the study.

Parkinson's disease patients diagnosed according to the diagnostic criteria of MDS