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| Name | Class |
|---|---|
| Blue Cross Blue Shield of Michigan Foundation | OTHER |
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This study will determine the safety and efficacy of using blood-flow restriction exercise enhancement (B-FREE) to overcome persistent quadriceps muscle weakness that occurs following a total knee replacement (TKR).
This study aims to determine the safety and efficacy of using B-FREE to overcome persistent quadriceps muscle weakness that occurs following a TKR. We hypothesize that B-FREE can provide a safe training stimulus and offer a home-based program to restore quadriceps muscle strength and improve functional mobility. Specifically, subjects that have a TKR will perform B-FREE at home (light weights with resistance bands and walking) 3x/wk for 10 weeks. Quadriceps muscle strength, balance, and functional mobility will be assessed before and after the program. Changes in these variables will be compared to healthy age-matched uninjured controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adults with TKR Perform Home Exercise Program | Experimental | Participants that have a total knee replacement will complete a home-based exercise program |
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| Healthy Controls Only | No Intervention | Participants that have no history of knee joint dysfunction will serve as age-matched uninjured controls |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| B-FREE | Other | Blood flow-restriction exercise enhancement (B-FREE) will be performed at home 3x/wk for 10 weeks. A blood pressure cuff will be inflated to partially occlude blood to the limb during light weight exercises involving knee extension, body weight squats, and walking. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Muscle size | quadriceps muscle thickness | Change from baseline at 10 weeks |
| Change in Muscle strength | quadriceps muscle strength | Change from baseline at 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Walking performance | walking distance | Change from baseline at 10 weeks |
| Change in Balance | balance assessment | Change from baseline at 10 weeks |
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Inclusion Criteria
Exclusion Criteria
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| Name | Affiliation | Role |
|---|---|---|
| Steven Elmer | Michigan Technological University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Michigan Technological University | Houghton | Michigan | 49931 | United States |
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| ID | Term |
|---|---|
| D007718 | Knee Injuries |
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D007869 | Leg Injuries |
| D014947 | Wounds and Injuries |
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
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| D007592 |
| Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |