Blood-Flow Restriction Exercise Following a Knee Replacement

B-FREE in the UP! Improving Recovery After a Knee Replacement With Blood-Flow Restriction Exercise Enhancement

This study will determine the safety and efficacy of using blood-flow restriction exercise enhancement (B-FREE) to overcome persistent quadriceps muscle weakness that occurs following a total knee replacement (TKR).

This study aims to determine the safety and efficacy of using B-FREE to overcome persistent quadriceps muscle weakness that occurs following a TKR. We hypothesize that B-FREE can provide a safe training stimulus and offer a home-based program to restore quadriceps muscle strength and improve functional mobility. Specifically, subjects that have a TKR will perform B-FREE at home (light weights with resistance bands and walking) 3x/wk for 10 weeks. Quadriceps muscle strength, balance, and functional mobility will be assessed before and after the program. Changes in these variables will be compared to healthy age-matched uninjured controls.

Inclusion Criteria

• 40-75 years of age
• Have had a unilateral TKA > 6 months prior to participation (Arm 1)
• No previous history of knee injury/surgery (Arm 2)

Exclusion Criteria

• Are a smoker
• Have diabetes
• Have suffered a heart attack or stroke
• Have any cardiopulmonary disorders (hypertension discussed below)
• Have been diagnosed with any neurological disorders
• Have any implanted devices such as but not limited to a pacemaker or pain pump
• Uncontrolled (not medicated) Stage 1 hypertension or Stage 2 hypertension