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| Name | Class |
|---|---|
| Haukeland University Hospital | OTHER |
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Non-obstructive coronary artery disease (CAD), particularly common in women, has been associated with impaired quality of life and risk of recurrent hospitalizations. Several studies have also demonstrated increased risk of incident acute coronary events and mortality.
The main objective of the project is to assess the association between coronary artery plaque features by coronary CT angiography and long term prognosis in a large unselected population undergoing CT coronary angiography due to stable angina and suspected myocardial ischemia from the Norwegian Registry for Invasive Cardiology (NORIC) diagnosed with non-obstructive CAD by coronary CT angiography.
Patients with stable angina and non-obstructive coronary artery disease by CT coronary angiography will be selected from the Norwegian Registry of Invasive Cardiology (NORIC). This is a national quality control registry run and controlled by the Norwegian Institute of Public Health (www.fhi.no). All CT coronary angiograms will be reanalyzed using advanced post-processing analysis software to assess coronary artery plaque burden, distribution and composition. Through linking with the Norwegian Cardiovascular Disease Registry and the Cause of Death Registry (www.fhi.no) we will be able to assess the association between long-term prognosis (5 years) and coronary artery plaque features.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High and low coronary artery plaque burden | Patients with high plaque burden defined as plaque in >=4 segments of the coronary tree and low plaque burden as plaque in <4 segments of the coronary tree assessed by postprocessing of CT coronary angiography images and cardiovascular events and mortality. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coronary artery plaque assessment by CT coronary angiography QAngio CT RE | Diagnostic Test | Assessment of segmental plaque volume and composition |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular mortality and nonfatal acute myocardial infarction | Composite of deaths caused by cardiovascular disease and nonfatal acute myocardial infarction | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| All-cause mortality, hospitalization due to cardiovascular disease and revascularization procedures | All-cause mortality, hospitalization due to cardiovascular disease and revascularization procedures | 5 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients from the NORIC registry undergoing CT coronary angiography due to chest pain and suspected myocardial ischemia and diagnosed with non-obstructive coronary artery disease between 2013-2017.
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| Name | Affiliation | Role |
|---|---|---|
| Mai Tone Lønnebakken, MD phd | University of Bergen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Clinical Science, University of Bergen | Bergen | 5021 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40645670 | Derived | Hondros CAB, Hanseth S, Solvik M, Pedersen EKR, Khan I, Hovland S, Larsen TH, Lonnebakken MT. Age-stratified differences in coronary artery plaque phenotypes in women and men with non-obstructive coronary artery disease. Open Heart. 2025 Jul 11;12(2):e003371. doi: 10.1136/openhrt-2025-003371. | |
| 40521640 | Derived |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D058226 | Plaque, Atherosclerotic |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| Khan I, Hondros CAB, Hanseth S, Pedersen ER, Hovland S, Larsen TH, Lonnebakken MT. Epicardial adipose tissue volume, compositional plaque progression, and vulnerability in nonobstructive coronary artery disease. Coron Artery Dis. 2025 Nov 1;36(7):580-586. doi: 10.1097/MCA.0000000000001539. Epub 2025 Jun 17. |
| 38356931 | Derived | Hondros CAB, Khan I, Solvik M, Hanseth S, Pedersen EKR, Hovland S, Larsen TH, Lonnebakken MT. Compositional plaque progression in women and men with non-obstructive coronary artery disease. Int J Cardiol Heart Vasc. 2024 Feb 7;51:101352. doi: 10.1016/j.ijcha.2024.101352. eCollection 2024 Apr. |
| 35061769 | Derived | Berge CA, Eskerud I, Almeland EB, Larsen TH, Pedersen ER, Rotevatn S, Lonnebakken MT. Relationship between hypertension and non-obstructive coronary artery disease in chronic coronary syndrome (the NORIC registry). PLoS One. 2022 Jan 21;17(1):e0262290. doi: 10.1371/journal.pone.0262290. eCollection 2022. |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |