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The number of elderly individuals affected by cardiovascular diseases has been increasing in our country. Garlic (Allium sativum) has been associated with decrease of reactive species of oxygen, hypertension, high cholesterol, platelet aggregation, blood coagulation and especially cardiovascular diseases. The present study evaluated the effects of a garlic supplementation on vascular function and blood pressure in the elderly at cardiometabolic risk. Twenty-eight elderly individuals were submitted to an ingestion of four capsules of an aged garlic extract (KYOLIC® Aged Garlic Extract™). Muscle oxygenation and function were measured 180 min after interventions. Urinary thiosulfate, blood nitrate, nitrite, systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at baseline and 180 min after interventions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Kyolic® Hi-Po Formula - Kyolic | Active Comparator | Aged garlic extract |
|
| Placebo | Placebo Comparator | Maltodextrin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aged Garlic Extract | Dietary Supplement | 2.400 mg (four capsules) of a nutritional supplement of aged garlic extract (Kyolic® Hi-Po Formula - Kyolic) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Near infrared spectroscopy 1 | microvascular endothelial function | 180 minutes after nutritional intervention |
| High performance liquid chromatography 1 | Urinary nitrate concentrations | Baseline and 180 minutes after nutritional intervention |
| High performance liquid chromatography 2 | Urinary thiosulfate concetrations | Baseline and 180 minutes after nutritional intervention |
| Near infrared spectroscopy 2 | muscle oxygenation saturated assessment | 180 minutes after nutritional intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Thiago Alvares | Universidade Federal do Rio de Janeiro - Campus Macaé | Study Director |
| Thiago Alvares | Universidade Federal do Rio de Janeiro - Campus Macaé | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidade Federal do Rio de Janeiro - Campus Macaé | Macaé | Rio de Janeiro | 27930-560 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35505122 | Derived | Leitao R, de Oliveira GV, Rezende C, Volino-Souza M, Mesquita J, de Carvalho LL, Alvares TS. Improved microvascular reactivity after aged garlic extract intake is not mediated by hydrogen sulfide in older adults at risk for cardiovascular disease: a randomized clinical trial. Eur J Nutr. 2022 Oct;61(7):3357-3366. doi: 10.1007/s00394-022-02895-y. Epub 2022 May 4. |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| D050171 | Dyslipidemias |
| D056128 | Obesity, Abdominal |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| Placebo | Other | 800 mg of maltodextrin (four capsules) |
|
| D009750 | Nutritional and Metabolic Diseases |
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |