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| Name | Class |
|---|---|
| Wakunaga Pharmaceutical Co., Ltd. | INDUSTRY |
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This is a randomized, double-blind, placebo controlled, crossover study to determine the antioxidant effect of aged garlic extract. This study will also compare the oxidative status in heavy smokers with that in non-smokers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Smoker subjects take 6 capsules once a day for 4 weeks. |
|
| Aged garlic extract | Experimental | Smoker subjects take 1.5 g of aged garlic extract in 6 capsules once a day for 4 weeks. |
|
| Non-smoker | No Intervention | Oxidative status in non-smoker |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Dietary Supplement |
| ||
| Aged garlic extract |
| Measure | Description | Time Frame |
|---|---|---|
| Urinary 8-hydroxydeoxyguanosine (8-OHdG) | Every 4 weeks (Overall 12 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| High sensitive CRP | Every 4 weeks (Overall 12 weeks) | |
| Blood pressure | Every 4 weeks (Overall 12 weeks) | |
| Indices of the second derivative of photoplethysmogram (SDPTG) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Fumiko Higashikawa, PhD | Hiroshima University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hiroshima University | Hiroshima | Hiroshima | 734-8551 | Japan |
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| Every 4 weeks (Overall 12 weeks) |