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our study aimed to evaluate the effect of nebulized lidocaine to decrease the incidence of cough and sore throat after extubation after surgeries requiring endotracheal intubation.
our study aimed to evaluate the effect of nebulized lidocaine to decrease the incidence of cough and sore throat after extubation after surgeries requiring endotracheal intubation.
This randomized controlled study will compare the effect of Lidocaine and placebo nebulization in the immediate pre operative period in order to evaluate the effectiveness in reducing post extubation cough and sore throat.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| lidocaine group | Active Comparator | the patients of this group will recieve nebulization of 5 ml of 2% lidocaine prior to induction of general anesthesia |
|
| Placebo group | Placebo Comparator | the patients of this group will recieve nebulization of 5 ml of normal saline prior to induction of general anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lidocaine 2% | Drug | the patients of this group will recieve nebulization of 5 ml of 2% lidocaine prior to induction of general anesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| incidence of cough at emergence from general anesthesia | evaluation of incidence of cough at emergence from general anesthesia | 30 minutes after the end of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of sore throat | evaluation of incidence of sore throat | 24 hours after tracheal extubation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mhamed Sami Mebazaa, professor | Contact | 0021622252589 | msmebazaa@gmail.com | |
| Hajer Arfaoui | Contact | 0021699336661 | hejer_arfaoui@hotmail.fr |
| Name | Affiliation | Role |
|---|---|---|
| Mhamed Sami Mebazaa, Professor | Mongi Slim Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mongi Slim Hospital | Recruiting | La Marsa | Tunis Governorate | 2046 | Tunisia |
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| ID | Term |
|---|---|
| D003371 | Cough |
| D010612 | Pharyngitis |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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2 groups comparaison between nebulized lidocaine versus placebo for prevention of cough at emergence from general anesthesia and post extubation sore throat
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The investigator will provide to the anesthesiologist 1 seringue containing either lidocaine or normal saline to be nebulized before induction of general anesthesia
| Normal saline | Drug | Normal saline |
|
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
| D010038 | Otorhinolaryngologic Diseases |