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The purpose of this study is to test the hypothesis that use of preoperative nebulized lidocaine is reduced the incidence of postoperative sore throat after endotracheal intubation.
Adult patients undergoing video-assisted thoracic surgery (VATS) requiring double lumen tube (DLT) endotracheal intubation for one-lung ventilation (OLV) were enrolled in the study. Patients were randomized by means of computer-generated order randomization into two groups: Group C (those who received a saline solution as placebo delivered by nebulization) and Group L (those who received lidocaine delivered by nebulization).
At 1, 6 and 24 h after tracheal extubation, an observer blinded to treatments evaluated the patients in terms of sore throat and hoarseness. In addition, Patients' satisfaction, intraoperative and postoperative opioid and analgesics consumption and complaints such as dysphagia, nausea and vomiting were recorded. Hemodynamic variables such as blood pressure and heart rate were also recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group C | Active Comparator | In Control Group, 4 mL of saline solution was administered using a face mask and a compressed gas-powered jet nebulizer for 15 min |
|
| Group L | Active Comparator | In Lidocaine Group 4 mL of 4% lidocaine was administered using a face mask and a compressed gas-powered jet nebulizer for 15 min |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Saline | Other | Effect of saline on postoperative sore throat |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in the incidence of postoperative sore throat | Sore throat was assessed using a 0-100 mm visual analog scale (VAS), where a score of 0 represents no pain and a score of 100 reflects the worst pain imaginable. | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| whether the hoarseness was present or not | Hoarseness was defined as a change in voice quality and it was assessed by the patients themselves. The change in voice quality at any time during the observation period was defined as "hoarseness was present". | 24 hours |
| Intraoperative opioid consumption |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ali Sait Kavakli, MD | Antalya Training and Research Hospital | Principal Investigator |
| Hilal Yavuzel, MD | Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital | Principal Investigator |
| Ulku Arslan, MD | Karabuk University Training and Research Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Antalya Training and Research Hospital | Antalya | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D010612 | Pharyngitis |
| ID | Term |
|---|---|
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| D008012 | Lidocaine |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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| Lidocaine |
| Other |
Effect of nebulized lidocaine on postoperative sore throat |
|
Assessed in intraoperative period |
| 60 minutes |
| Postoperative analgesic consumption | Assessed in postoperative period | 24 hours |
| Changes in mean arterial pressure | Assessed every 5 minutes during the procedure | 60 minutes |
| Changes in heart rate | Assessed every 5 minutes during the procedure | 60 minutes |
| D012140 |
| Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D017670 |
| Sodium Compounds |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |