Effect of Thiamin Supplementation on Thiamin Status in Children With Heart Disease Receiving Diuretic Drugs

Effect of Thiamin Supplementation on Thiamin Status in Children With Heart Disease Receiving Diuretic Drugs: Randomized Controlled Trial

The purpose of this study is to determine effect of thiamin supplementation on thiamin status by measuring thiamin pyrophosphate effect in children with heart disease receiving diuretic drugs.

Children with heart disease receiving diuretic drugs are susceptible to thiamin deficiency due to increase renal loss. Thiamin deficiency causes abnormal cardiac contraction resulting in heart failure.

Inclusion Criteria:

• Children aged 1 month old to 15 years old diagnosed as heart disease
• Receiving diuretic drugs at least 1 month

Exclusion Criteria:

• Receiving thiamin-containing vitamins
• Receiving hemodialysis or peritoneal dialysis
• Having problems of intestinal malabsorption, chronic lung disease, red blood cell abnormality such as thalassemia , abnormal hemoglobin typing, G6PD deficiency
• Receiving thiamin-producing probiotics
• Receiving inotropic drugs
• Severe anemia: Hb < 7 g/dL