Pharmacokinetics of Oral Thiamine

Pharmacokinetics of High Dose Oral Thiamine

Elevated levels of thiamine may increase cellular energy metabolism by increasing the activity of pyruvate dehydrogenase complex. This has been hypothesized to have a beneficial affect in patients with several diseases including sepsis, heart failure, and diabetes. There is limited data on the pharmacokinetics of supraphysiologic doses of oral thiamine.

The aims of this study are to:

• Calculate the plasma and whole blood pharmacokinetics of supraphysiologic doses of oral thiamine in healthy volunteers;
• Compare the different thiamine doses on the pharmacokinetic variables using repeated measures ANOVA.

Inclusion Criteria:

• Age between 18 and 55

Exclusion Criteria:

• Non dietary thiamine supplement within two weeks of the start of the study or during the study
• History of thiamine deficiency
• Anemia (Hgb<10)
• History of gastrointestinal absorption disorders
• Taking prescription or over-the-counter medication
• Pregnant or breast feeding a child
• Alcohol and or drug abuse
• Smoker