Rosacea is a common skin disorder which causes facial redness and inflammation in about 16 million Americans, from an unknown cause. Many triggers of rosacea symptoms are stressors that affect the sympathetic ("fight or flight") portion of the nervous system, and a recent pilot study suggests there is sympathetic dysfunction in rosacea. This project will benefit patients, clinicians, and basic scientists by increasing our understanding of sympathetic nervous system involvement in rosacea symptoms in order to develop improved treatments for patients with rosacea.

Inclusion Criteria:

• Otherwise healthy males and non-pregnant/non-lactating females with mild to moderate erythematotelangiectactic rosacea, as well as age-sex matched healthy control subjects.

Exclusion Criteria:

• Neurological, cardiovascular, respiratory, metabolic, muscular, or other dermatological disorders
• Current history of alcohol and/or drug abuse
• Known allergies or hypersensitivities to medications/drugs that are used in the protocol
• Current smoking or regular smoking within the last 2 years
• Body mass index > 35 kg/m2
• Medications or supplements which are known to affect neural, cardiovascular, or muscular responses