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To compare of effects of volatile and intravenous anesthetics on pupillary function during general anesthesia in children
The investigator will measure the pupillary function with pupillometry during general anesthesia with volatile or intravenous anesthetics in children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sevoflurane+Remifentanil | Using inhalent agent(Sevoflurane), continuous infusion of Remifentanil |
| |
| Propofol+Remifentanil | Using continuous infusion of Propofol and Remifentanil |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sevoflurane | Other | volatile anesthetic |
| |
| propofol |
| Measure | Description | Time Frame |
|---|---|---|
| NPi | Neurological Pupil index | 1hour afer skin incision |
| Measure | Description | Time Frame |
|---|---|---|
| %CH | % change of pupil size | 1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation |
| CV |
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Inclusion Criteria:
Exclusion Criteria:
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From other study results, average NPi for Sevoflurane and propofol were 3.6, 4.2, and standard deviation was 0.1, 0.4 respectively. Using Gpower program, total of 18 patients were required. Considering 20% of drop-out rate, total of 22 patients(18+3.6 patients) were to be recruited.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sang-Hwan Ji, M.D., M.S. | Contact | +82-2-2072-3661 | taepoongshin@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Hee-Soo Kim, M.D., Ph.D. | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Recruiting | Seoul | 03080 | South Korea |
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| ID | Term |
|---|---|
| D011681 | Pupil Disorders |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D005128 | Eye Diseases |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077149 | Sevoflurane |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
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| Other |
intravenous anesthetic |
|
Constriction Velocity
| 1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation |
| DV | Dilation Velocity | 1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation |
| NPi | Neurological Pupil index | 1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D006846 |
| Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |