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vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues production in vessel wall and it has some important functions in platelets.
In this randomized clinical trial, 1000 mg vitamin C will administrate intravenously a day before surgery and during surgery in patients who undergo abdominal hysterectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| vitamin C | Experimental | Intervention patients will be received double dose of Ascorbic acid via intravenous injection |
|
| Control | No Intervention | Control patients will not be received any intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| vitamin C | Drug | water-soluble vitamin C injection contain of 1000 mg vitamin C that given via intravenous injection |
|
| Measure | Description | Time Frame |
|---|---|---|
| volume of hemorrhage | volume of hemorrhage during surgery | During surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Hemoglobin value | Hemoglobin value after surgery | 6 and 24 hours after surgery |
| wound healing | complications after surgery | during 2 weeks post surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| zahra vahdat shariatpanahi, MD,PhD | Associatec professor | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences | Tehran | Iran |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35623878 | Derived | Farahani-Jam S, Yaghmaei M, Vahdat Shariatpanahi Z. Effect of intravenous ascorbic acid administration on hemorrhage and wound complications in total abdominal hysterectomy: A prospective randomized clinical trial. Clin Nutr ESPEN. 2022 Jun;49:74-78. doi: 10.1016/j.clnesp.2022.03.024. Epub 2022 Mar 26. |
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| ID | Term |
|---|---|
| D006470 | Hemorrhage |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D001205 | Ascorbic Acid |
| ID | Term |
|---|---|
| D013400 | Sugar Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| duration of stay in hospital | Length of stay in hospital | up to 2 weeks post surgery |
| Infection | Developing infection up to 2 weeks | up to 2 weeks post surgery |
| D006880 |
| Hydroxy Acids |
| D002241 | Carbohydrates |