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| ID | Type | Description | Link |
|---|---|---|---|
| 17C195 | Other Grant/Funding Number | Novartis Foundation for medical-biological research |
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| Name | Class |
|---|---|
| Novartis | INDUSTRY |
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Decisions are part of the daily life. On the neuronal level, activity in the dorsolateral prefrontal cortex (dlPFC) is important during complex decisions (e.g., whether something is emotional for a person or not). We apply transcranial direct current stimulation (tDCS) with the aim to increase dlPFC activity and thereby modulate decisions towards emotional content.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Real tDCS | Experimental | 20 min of 1 mA real anodal transcranial direct current stimulation applied via 5x7 cm rubber electrodes over the DLPFC (current density: 0.028 mA/cm2). Additional ramp-up and ramp-down phase at beginning and end of stimulation lasting for 15 s. Electrodes remain attached to the participant's head for the duration of the decision task. |
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| Sham tDCS | Sham Comparator | 30 s of 1 mA anodal tDCS applied via 5x7 cm rubber electrodes over the DLPFC (current density: 0.028 mA/cm2). Additional ramp-up and ramp-down phase at beginning and end of stimulation lasting for 15 s. Electrodes remain attached to the participant's head for the duration of the decision task. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| real anodal transcranial direct current stimulation | Device | A neuroConn DC-Stimulator PLUS (neuroCare Group, Ilmenau, Germany) will be used. |
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| Measure | Description | Time Frame |
|---|---|---|
| Influence of Stimulation on the Decisions | Number of words which were rated as positive or negative. | 10 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Profile of Mood States (POMS; before stimulation) | Changes in the subjective measure mood, assessed with questionnaire Scores for each item is recorded as 0 for "not at all" up to 6 for "very strong". A Total Mood Disturbance (TMD) score is calculated by summing the totals for the negative subscales dejection (14 items), fatigue (7 items) and discontent (7 items) and then subtracting the total for the positive subscale zest (7 items). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jessica Peter, PD | Universitäre psychiatrische Dienste Bern (UPD), University of Bern | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Klinik für Alterspsychiatrie und Psychotherapie UPD Bern | Bern | 3000 | Switzerland |
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Participants are allocated to one of 2 groups: real tDCS or sham.
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Double blind design
| sham transcranial direct current stimulation | Device | A neuroConn DC-Stimulator PLUS (neuroCare Group, Ilmenau, Germany) will be used. |
|
| 3 minutes |
| Profile of Mood States (POMS; after stimulation) | Changes in the subjective measure mood, assessed with questionnaire Scores for each item is recorded as 0 for "not at all" up to 6 for "very strong". A Total Mood Disturbance (TMD) score is calculated by summing the totals for the negative subscales dejection (14 items), fatigue (7 items) and discontent (7 items) and then subtracting the total for the positive subscale zest (7 items). | 3 minutes |
| Positive and Negative Affect Schedule (PANAS; before stimulation) | Changes in the subjective measure mood, assessed with self-report questionnaire divided into two mood scales. One scale measures a person's positive emotion and the other scale measures the negative. Each segment has ten terms, which can be rated on a scale of 1 to 5 to indicate the extent to which the respondent agrees that this applies to him (higher values means higher agreement). | 2 minutes |
| Positive and Negative Affect Schedule (PANAS; after stimulation) | Changes in the subjective measure mood, assessed with self-report questionnaire divided into two mood scales. One scale measures a person's positive emotion and the other scale measures the negative. Each segment has ten terms, which can be rated on a scale of 1 to 5 to indicate the extent to which the respondent agrees that this applies to him (higher values means higher agreement). | 2 minutes |