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The purpose of this study is to observe the effects of exogenous ketone supplements during shorter bouts of exercise testing on twenty collegiate endurance trained athletes (18-25 years of age).
Some believe very high fat diets (>70% energy) can enhance exercise performance by providing additional fuel (ketones) for energy metabolism, at least for very prolonged exercise (>3-4h). Regardless, this diet is difficult to maintain so it has been suggested that ingesting ketone salts along with a normal carbohydrate (CHO) diet might be more practical. The purpose of this study is to observe the effects of ketone salt ingestion on shorter term (up to ~15 min) exercise performance. Endurance trained (≥2 year training experience; ≥7 h/week) collegiate athletes (n=20) of similar body mass (♀; 55-60kg; ♂; 75-80kg) and age 18-25y) consuming 5-6g CHO•kg-1•d-1) will be tested before and after 1 and 7d of ketone salt (Prüvit, Carrollton TX, US) supplementation (0.6-0.8g•kg-1•d-1). Participants will perform two exercise performance tests (a 10km cycle time trial and a 30s Wingate cycle test on separate days) before and after supplementation. Blood samples (glucose, lactic acid, and ketone concentration) will be taken at: baseline and following each performance test. It is hypothesized that ketone salt supplementation will increase blood ketone concentration but will not enhance these exercise performance tests.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Baseline Testing | Active Comparator | Baseline testing for a 10km cycle time trial and a 30s Wingate cycle test. |
|
| Dietary Supplement: Exogenous Ketone Salt | Experimental | Ketone salt supplementation (0.6-0.8g•kg-1•d-1) 7-days. Participants will perform two exercise performance tests (a 10km cycle time trial and a 30s Wingate cycle test on separate days) after supplementation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 10 km time trial | Behavioral | 10 km Cycling time trial test will be conducted to examine the effects of the Exogenous Ketone Salts on time |
|
| Measure | Description | Time Frame |
|---|---|---|
| 10 km Time trial | 10km time trial where participants will be measured on time to completion | 15-20 Minutes |
| 30s Wingate | 30s Wingate all out test where participants will be measured on their peak power output | 30 seconds |
| Measure | Description | Time Frame |
|---|---|---|
| Blood Ketones | Blood Ketones will be measured using a ketone meter | 1-2 hours |
| Blood Glucose | Blood Glucose will be measured using a Blood glucose meter |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sydney EL Isbell, BSc | Contact | 5196612111 | sisbell@uwo.ca | |
| Manuel D Quinones, MSc | Contact | 5196612111 |
| Name | Affiliation | Role |
|---|---|---|
| Peter WR Lemon, PhD | Western University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Exercise Nutrition Laboratory, Western University | London | Ontario | N6A3K7 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29451991 | Background | Waldman HS, Basham SA, Price FG, Smith JW, Chander H, Knight AC, Krings BM, McAllister MJ. Exogenous ketone salts do not improve cognitive responses after a high-intensity exercise protocol in healthy college-aged males. Appl Physiol Nutr Metab. 2018 Jul;43(7):711-717. doi: 10.1139/apnm-2017-0724. Epub 2018 Feb 16. | |
| 28750585 | Background |
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| ID | Term |
|---|---|
| D007662 | Ketosis |
| ID | Term |
|---|---|
| D000138 | Acidosis |
| D000137 | Acid-Base Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D007659 | Ketones |
| C074807 | BaseLine dental cement |
| ID | Term |
|---|---|
| D009930 | Organic Chemicals |
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| 30s Wingate | Behavioral | 30s all-out test to measure peak power output |
|
| Ketone | Dietary Supplement | Supplement containing exogenous ketone salts |
|
| Baseline 10 km time trial | Behavioral | A baseline 10 km Cycling time trial test will be conducted |
|
| Baseline 30s Wingate | Behavioral | A baseline 30s all-out test to measure peak power output |
|
| 1-2 hours |
| Blood Lactate | Blood Lactate will be measured using a lactate meter | 1-2 hours |
| O'Malley T, Myette-Cote E, Durrer C, Little JP. Nutritional ketone salts increase fat oxidation but impair high-intensity exercise performance in healthy adult males. Appl Physiol Nutr Metab. 2017 Oct;42(10):1031-1035. doi: 10.1139/apnm-2016-0641. Epub 2017 Jul 27. |
| 25275931 | Result | Volek JS, Noakes T, Phinney SD. Rethinking fat as a fuel for endurance exercise. Eur J Sport Sci. 2015;15(1):13-20. doi: 10.1080/17461391.2014.959564. Epub 2014 Oct 2. |