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A cohort of hypertension patients undergoing elective non-cardiac surgery was constructed to investigate current status of antihypertensive drug treatment in non-cardiac surgical population.
Perioperative changes in blood pressure (BP) are associated with perioperative risks. However, there is little information regarding the current status of antihypertensive treatment in non-cardiac surgical population. A cohort of 351 hypertension patients aged between 18 to 85-year old undergoing elective non-cardiac surgery was constructed to investigate the application of antihypertensive drugs, systemic involvement, perioperative hemodynamics and internal environment to grasp the perioperative impact of different antihypertensive drugs, and to further provide a reference for the preoperative antihypertensive strategy of surgery patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ARB | Group of angiotensin receptor blockers(ARB) monotherapy users. A subject was considered as an ARB user when the total prescription days of ARB monotherapy was at least 30. | ||
| combination of CCB and ARB | Group of calcium channel blockers(CCB) and angiotensin receptor blockers(ARB) combination users. A subject was considered as a CCB and ARB combination user when the total prescription days of CCB and ARB combination therapy was at least 30. | ||
| CCB | Group of calcium channel blockers(CCB) monotherapy users. A subject was considered as a CCB user when the total prescription days of CCB monotherapy was at least 30. | ||
| No treatment | Group of nonusers of antihypertensives. A subject was considered as a nonuser never received regular antihypertensive treatment or total prescription days of antihypertensives was less than 30. |
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| Measure | Description | Time Frame |
|---|---|---|
| perioperative blood press(BP) | baseline BP before the operation, when entering and exiting post-anesthesia care unit(PACU) | from the moment on arrival to the operating room until the moment leaving PACU, assessed up to 240 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| pH, base excess, and concentration of HCO3- in blood gases | arterial blood gases detected by using the ABL800 (Radiometer Med Aps Ltd, Copenhagen, Denmark) | 5 minutes after extubating in PACU |
| the incidence of hypotension in PACU |
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Inclusion Criteria:
Exclusion Criteria:
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patients undergoing elective non-cardiac surgery in Renji hospital
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| Name | Affiliation | Role |
|---|---|---|
| Jie Chen, M.S. | Renji Hospital, School of Medicine, Shanghai Jiaotong University, China | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Renji Hospital, Shanghai Jiao Tong University, School of Medicine | Shanghai | Shanghai Municipality | 200127 | China |
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If there were more than two consecutive episodes of hypotension (which was defined as SBP less than 80% of baseline) a "rescue" intravenous bolus of 100 mg of phenylephrine was given.
| from the moment on arrival to PACU until 60 minutes after arriving or the moment leaving PACU, whichever came first, assessed up to 240 minutes. |
| the incidence of hypertension in PACU | the incidence of hypertension, which was defined as SBP greater than 120% of baseline | from the moment on arrival to PACU until 60 minutes after arriving or the moment leaving PACU, whichever came first, assessed up to 240 minutes. |
| hospitalization days | The duration of this single episode of hospitalization | from the date of admission until the date of discharge or date of death from any cause, whichever came first, assessed up to 100 days |