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| ID | Type | Description | Link |
|---|---|---|---|
| 16503 | Other Identifier | REB |
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Patients on a stable dose of ACE inhibitor or ARB medication who are scheduled for elective surgery will be randomized to take their ACE inhibitor or ARB up to and including the morning of surgery, or to hold them a day prior to the surgery. The patients will be followed for 30 days after surgery to assess any adverse health outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Continuing ACEi/ARB | Active Comparator | Patients in this group will continue to take their chronic ACEi/ARB medications up to and including the day of surgery. |
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| Holding ACEi/ARB | Active Comparator | Patients in this arm will hold their chronic ACEi/ARB medication at least 24 hours prior to surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Preoperative ACEi/ARB management | Procedure | Patients will either hold their chronic ACEi/ARB medication for at least 24 hours prior to surgery, or continue to take the ACEi/ARB medication up to and including the day of surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Mean arterial blood pressure | 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Clinically significant hypotension | 30 days after surgery | |
| Clinically significant hypertension | 30 days after surgery | |
| All-cause mortality |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marko Mrkobrada, MD | University of Western Ontario, Canada | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| London Health Sciences Centre | London | Ontario | N6A 5A5 | Canada |
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| 30 days after surgery |
| Cardiovascular morbidity | 30 days after surgery |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D007022 | Hypotension |
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
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