Effect of Aging & Obesity With Exercise Intervention

Biphasic and Combined Effect of Aging & Obesity With Development of Effective Exercise Intervention Protocol

Obesity leads to a vicious circle that increases intramuscular fat, insulin resistance, promotes muscular dysfunction resulting in increased muscle fat accumulation. The study of muscle function and intramyocellular lipids is insufficient for obesity. Particularly, the study of mechanisms in muscle function and intramyocellular lipids is few nationally and internationally.

This study is prospective study. The goal of this study is

1. To examine the distribution and contractile properties (cross-sectional area, maximal force, specific force, maximal shortening velocity) of single muscle fiber sex/Myosin heavy chain (MHC) type-related differences, by extracting a single muscle fiber from the vastus lateralis in young men and women.
2. To examine the effects of intramyocellular lipids on physical activity ability, muscle dysfunction, and metabolic disorders in relation to aging and obesity.
3. To examine the effects of intramyocellular lipids on physical activity ability, muscular dysfunction, and metabolic disorders after 12 weeks resistance exercise intervention.

Inclusion Criteria:

• Young men: Age (20-35 yrs), BMI (19-23 Kg/m2)
• Young women: Age (20-35 yrs), BMI (19-23 Kg/m2)
• Elderly women: Age (65-80 yrs), BMI (19-23 Kg/m2)
• Elderly obese women: Age (65-80 yrs), BMI ( >25 Kg/m2)
• Subjects who can agree voluntarily.

Exclusion Criteria:

• Acute coronary syndrome.
• Uncontrolled hypertension.
• Subjects who took drugs which can affects neuromuscular system.
• Severely impaired cognition
• Subjects who cannot agree voluntarily