Smoking Cessation Behavioral Treatment Study

Neural Mechanisms Mediating Appetitive Regulation and Smoking in Nicotine Addiction

The purpose of this study is to evaluate the effectiveness of two behavioral interventions on smoking behavior - Mindfulness-Oriented Recovery Enhancement (MORE) and Cognitive Behavioral Therapy (CBT). MORE is a behavioral therapy that integrates mindfulness training to modify reward processes. CBT is a therapy designed to help individuals understand how their thoughts and feelings influence their behaviors.

Inclusion Criteria:

• Age 18 and up
• English fluency as demonstrated in providing informed consent and the ability to independently follow directions in completing assigned assessments and tasks
• Functional vision (with corrective lenses as needed) to complete assigned assessments and tasks
• Current nicotine dependent smoker with a minimum smoking history of 2 years
• Interest in quitting smoking

Exclusion Criteria:

• Use of psychotropic (e.g. antiepileptic) medications in the past month
• Positive urine drug screen
• Presence of an untreated medical illness
• Current or past psychosis
• History of major neurological illness or head injury resulting in loss of consciousness
• And contraindication to MRI, including claustrophobia
• Among females, positive urine pregnancy test
• Inability or unwillingness of subject to give informed consent