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The purpose of this research study is to examine changes in brain regions associated with cognitive control and reward processing during behavioral smoking cessation treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CBT Treatment | Experimental | Participants receive Cognitive behavioral therapy (CBT). Participants will receive 4 one hour CBT treatments. |
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| Control Group | Active Comparator | Participants receive health education treatment. Participants will attend treatment sessions that match the CBT Treatment arm with respect to time and contact. |
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| Control Group - Scans | No Intervention | Participants in this new arm to the study will receive no intervention and will receive three scans. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive behavioral therapy | Behavioral | Therapy focused on explaining the physiological and psychological effects of nicotine. Training is focused on adherence to smoking instructions, physiological and psychological effects of nicotine, reviewing reasons for quitting, and coping with smoking urges. Smokers will be asked to begin smoking on a set schedule leading up to their quit day. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in activation in reward processing regions of the brain | Change from Baseline to Week 4 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in activation in cognitive control regions of the brain | Change from Baseline to Week 4 | |
| Change in connectivity between reward and cognitive control regions of the brain | Change from Baseline to Week 4 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Laura Martin, PhD | University of Kansas Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hoglund Brain Imaging Center, University of Kansas Medical Center | Kansas City | Kansas | 66160 | United States |
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| ID | Term |
|---|---|
| D016540 | Smoking Cessation |
| ID | Term |
|---|---|
| D015438 | Health Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D015928 | Cognitive Behavioral Therapy |
| ID | Term |
|---|---|
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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| Health education | Behavioral | Therapy that provides health education on the importance of healthy eating. Participants will be instructed to smoke as usual. |
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